Noncirrhotic Portal Hypertension: An Under-reported Late Adverse Event of SIRT in Metastatic Colorectal Cancer Patients

Introduction: Selective internal radiation therapy (SIRT) is increasingly used in different scenarios. Although portal hypertension (PHT) has been described as a nonclinically relevant finding after SIRT, its real incidence could have been neglected due to the nature of the diseases for which SIRT is indicated.

Case Reports: Here we report three cases with clinically relevant late PHT after treatments including SIRT and oxaliplatin among others.

Discussion: The sequential use of oxaliplatin and SIRT in patients with colorectal cancer metastases could have additive effects on the liver.