Exploitation of Enrofloxacin-loaded Docosanoic Acid Solid Lipid Nanoparticle Suspension As Oral and Intramuscular Sustained Release Formulations for Pig

Overview

Journal Drug Deliv

Specialty Pharmacology

Date 2019 Mar 19

PMID 30880494

Citations 7

Authors

Yanfei Tao

Fei Yang

Kuiyu Meng

Dongmei Chen

Yujuan Yang

Kaixiang Zhou

Wanhe Luo

Wei Qu

Yuanhu Pan

Zonghui Yuan

Shuyu Xie

Affiliations

Soon will be listed here.

Abstract

In our previous study, enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) could be effectively delivered to cells in vitro. In this study, its properties and exploitation as possible oral and intramuscular sustained release formulations for pigs were studied after being made into suspension. The re-dispersed time and sedimentation rate of the nanosuspension were 55 s and 1, respectively. It showed good stability when stored away from light and sustained release in pH = 7.4 PBS buffer. The suspension exhibited no irritation at the injection site and good palatability. Compared with commercial injection and soluble powder, the nanosuspension increased the bioavailability of enrofloxacin by 1.63 and 2.38 folds, and extended the mean residence time (MRT) of the drug from 11.27 and 12.33 to 37.76 and 35.15 h after intragastric and intramuscular administration, respectively. These results suggest that docosanoic acid SLN suspension (DAS) might be a promising oral and intramuscular sustained release formulation to enhance the pharmacological activity of enrofloxacin.

Citing Articles

Radiolabeled Trastuzumab Solid Lipid Nanoparticles for Breast Cancer Cell: in Vitro and in Vivo Studies.

Ozgenc E, Karpuz M, Arzuk E, Gonzalez-Alvarez M, Bermejo Sanz M, Gundogdu E ACS Omega. 2022; 7(34):30015-30027.

PMID: 36061662 PMC: 9435033. DOI: 10.1021/acsomega.2c03023.

Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo.

Pi C, Zhao W, Zeng M, Yuan J, Shen H, Li K Drug Deliv. 2022; 29(1):1878-1891.

PMID: 35748365 PMC: 9246235. DOI: 10.1080/10717544.2022.2086938.

Cefquinome Sulfate Oily Nanosuspension Designed for Improving its Bioavailability in the Treatment of Veterinary Infections.

Mao Y, Chen Y, Liu C, He X, Zheng Y, Chen X Int J Nanomedicine. 2022; 17:2535-2553.

PMID: 35677677 PMC: 9169852. DOI: 10.2147/IJN.S348822.

pH-driven entrapment of enrofloxacin in casein-based nanoparticles for the enhancement of oral bioavailability.

Yuan Z, Deng S, Chen L, Hu Y, Gu J, He L Food Sci Nutr. 2021; 9(8):4057-4067.

PMID: 34401057 PMC: 8358345. DOI: 10.1002/fsn3.2224.

Incorporation of Antibiotics into Solid Lipid Nanoparticles: A Promising Approach to Reduce Antibiotic Resistance Emergence.

Arana L, Gallego L, Alkorta I Nanomaterials (Basel). 2021; 11(5).

PMID: 34068834 PMC: 8151913. DOI: 10.3390/nano11051251.

References

Mehnert W, Mader K . Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2001; 47(2-3):165-96. DOI: 10.1016/s0169-409x(01)00105-3. View

Elsheikh H, Taha A, Khalafallah A, Osman I . Disposition kinetics of enrofloxacin (Baytril 5%) in sheep and goats following intravenous and intramuscular injection using a microbiological assay. Res Vet Sci. 2002; 73(2):125-9. DOI: 10.1016/s0034-5288(02)00020-6. View

Haritova A, Lashev L, Pashov D . Pharmacokinetics of enrofloxacin in lactating sheep. Res Vet Sci. 2003; 74(3):241-5. DOI: 10.1016/s0034-5288(03)00003-1. View

Martinez M, McDermott P, Walker R . Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals. Vet J. 2005; 172(1):10-28. DOI: 10.1016/j.tvjl.2005.07.010. View

Luo Y, Chen D, Ren L, Zhao X, Qin J . Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability. J Control Release. 2006; 114(1):53-9. DOI: 10.1016/j.jconrel.2006.05.010. View

Elmas M, Uney K, Yazar E, Karabacak A, Tras B . Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits. Res Vet Sci. 2006; 82(2):242-5. DOI: 10.1016/j.rvsc.2006.06.008. View

Xie S, Wang S, Zhao B, Han C, Wang M, Zhou W . Effect of PLGA as a polymeric emulsifier on preparation of hydrophilic protein-loaded solid lipid nanoparticles. Colloids Surf B Biointerfaces. 2008; 67(2):199-204. DOI: 10.1016/j.colsurfb.2008.08.018. View

Xie S, Pan B, Wang M, Zhu L, Wang F, Dong Z . Formulation, characterization and pharmacokinetics of praziquantel-loaded hydrogenated castor oil solid lipid nanoparticles. Nanomedicine (Lond). 2010; 5(5):693-701. DOI: 10.2217/nnm.10.42. View

Xie S, Zhu L, Dong Z, Wang X, Wang Y, Li X . Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids. Colloids Surf B Biointerfaces. 2011; 83(2):382-7. DOI: 10.1016/j.colsurfb.2010.12.014. View

10.

Wang Y, Zhu L, Dong Z, Xie S, Chen X, Lu M . Preparation and stability study of norfloxacin-loaded solid lipid nanoparticle suspensions. Colloids Surf B Biointerfaces. 2012; 98:105-11. DOI: 10.1016/j.colsurfb.2012.05.006. View

11.

Ji H, Tang J, Li M, Ren J, Zheng N, Wu L . Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin. Drug Deliv. 2014; 23(2):459-70. DOI: 10.3109/10717544.2014.918677. View

12.

Harada K, Usui M, Asai T . Application of enrofloxacin and orbifloxacin disks approved in Japan for susceptibility testing of representative veterinary respiratory pathogens. J Vet Med Sci. 2014; 76(10):1427-30. PMC: 4221182. DOI: 10.1292/jvms.14-0266. View

13.

Yang F, Kang J, Yang F, Zhao Z, Kong T, Zeng Z . Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats. J Vet Sci. 2015; 16(2):157-64. PMC: 4483498. DOI: 10.4142/jvs.2015.16.2.157. View

14.

Javed Ansari M, Anwer M, Jamil S, Al-Shdefat R, Ali B, Ahmad M . Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats. Drug Deliv. 2015; 23(6):1972-9. DOI: 10.3109/10717544.2015.1039666. View

15.

Tiwari R, Polk A, Patil H, Ye X, Pimparade M, Repka M . Rat Palatability Study for Taste Assessment of Caffeine Citrate Formulation Prepared via Hot-Melt Extrusion Technology. AAPS PharmSciTech. 2015; 18(2):341-348. PMC: 5599141. DOI: 10.1208/s12249-015-0447-1. View

16.

Ruennarong N, Wongpanit K, Sakulthaew C, Giorgi M, Kumagai S, Poapolathep A . Dispositions of enrofloxacin and its major metabolite ciprofloxacin in Thai swamp buffaloes. J Vet Med Sci. 2015; 78(3):397-403. PMC: 4829506. DOI: 10.1292/jvms.15-0464. View

17.

Li X, Xie S, Pan Y, Qu W, Tao Y, Chen D . Preparation, characterization and pharmacokinetics of doxycycline hydrochloride and florfenicol polyvinylpyrroliddone microparticle entrapped with hydroxypropyl-β-cyclodextrin inclusion complexes suspension. Colloids Surf B Biointerfaces. 2016; 141:634-642. DOI: 10.1016/j.colsurfb.2016.02.027. View

18.

Xie S, Yang F, Tao Y, Chen D, Qu W, Huang L . Enhanced intracellular delivery and antibacterial efficacy of enrofloxacin-loaded docosanoic acid solid lipid nanoparticles against intracellular Salmonella. Sci Rep. 2017; 7:41104. PMC: 5253767. DOI: 10.1038/srep41104. View

19.

Soliman G . Nanoparticles as safe and effective delivery systems of antifungal agents: Achievements and challenges. Int J Pharm. 2017; 523(1):15-32. DOI: 10.1016/j.ijpharm.2017.03.019. View