Elevated Autoimmunity in Residents Living Near Abandoned Uranium Mine Sites on the Navajo Nation

Overview

Journal J Autoimmun

Specialty Allergy & Immunology

Date 2019 Mar 18

PMID 30878168

Citations 24

Authors

Esther Erdei

Chris Shuey

Bernadette Pacheco

Miranda Cajero

Johnnye Lewis

Robert L Rubin

Affiliations

Soon will be listed here.

Abstract

Specific autoantibodies were assessed among residents of the Navajo Nation in New Mexico chronically exposed to metal mixtures from uranium mine wastes and in drinking water supplies. Age and the extent of exposure to legacy waste from 100 abandoned uranium mine and mill sites were associated with antibodies to denatured DNA, previously known to be an early indicator of medication-induced autoimmunity. Surprisingly, autoantibodies to native DNA and/or chromatin were also linked to environmental exposure, specifically uranium consumption through drinking water for both men and women, while urinary arsenic was negatively associated with these autoantibodies in women. These findings suggest that contaminants derived from uranium mine waste enhanced development of autoantibodies in some individuals, while arsenic may be globally immunosuppressive with gender-specific effects. Specific autoantibodies may be a sensitive indicator of immune perturbation by environmental toxicants, an adverse effect not considered in current drinking water standards or regulatory risk assessment evaluations.

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References

Brugge D, Goble R . The history of uranium mining and the Navajo people. Am J Public Health. 2002; 92(9):1410-9. PMC: 3222290. DOI: 10.2105/ajph.92.9.1410. View

Arbuckle M, McClain M, Rubertone M, Scofield R, Dennis G, James J . Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003; 349(16):1526-33. DOI: 10.1056/NEJMoa021933. View

Burlingame R, Rubin R . Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J Immunol Methods. 1990; 134(2):187-99. DOI: 10.1016/0022-1759(90)90380-e. View

Xia X, Lin S, Zhou Y . [Effects of arsenic trioxide on the autoimmunity and survival time in BXSB lupus mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007; 27(2):138-41. View

Lindberg A, Ekstrom E, Nermell B, Rahman M, Lonnerdal B, Persson L . Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh. Environ Res. 2007; 106(1):110-20. DOI: 10.1016/j.envres.2007.08.011. View

Shoenfeld Y, Blank M, Abu-Shakra M, Amital H, Barzilai O, Berkun Y . The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases--2008. Isr Med Assoc J. 2008; 10(1):13-9. View

Gardner R, Nyland J, Silva I, Ventura A, de Souza J, Silbergeld E . Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study. Environ Res. 2010; 110(4):345-54. PMC: 2873228. DOI: 10.1016/j.envres.2010.02.001. View

Satoh M, Chan E, Ho L, Rose K, Parks C, Cohn R . Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum. 2012; 64(7):2319-27. PMC: 3330150. DOI: 10.1002/art.34380. View

Miller F, Alfredsson L, Costenbader K, Kamen D, Nelson L, Norris J . Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J Autoimmun. 2012; 39(4):259-71. PMC: 3496812. DOI: 10.1016/j.jaut.2012.05.002. View

10.

Maier N, Crown D, Liu J, Leppla S, Moayeri M . Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes. J Immunol. 2013; 192(2):763-70. PMC: 3884817. DOI: 10.4049/jimmunol.1301434. View

11.

Furlow B . Uranium mines: lung disease and mistrust among Native Americans. Lancet Respir Med. 2014; 2(3):178-9. DOI: 10.1016/s2213-2600(14)70005-0. View

12.

Mehra S, Fritzler M . The spectrum of anti-chromatin/nucleosome autoantibodies: independent and interdependent biomarkers of disease. J Immunol Res. 2014; 2014:368274. PMC: 3996305. DOI: 10.1155/2014/368274. View

13.

Ahmed S, Moore S, Kippler M, Gardner R, Hawlader M, Wagatsuma Y . Arsenic exposure and cell-mediated immunity in pre-school children in rural Bangladesh. Toxicol Sci. 2014; 141(1):166-75. PMC: 4833103. DOI: 10.1093/toxsci/kfu113. View

14.

Lu-Fritts P, Kottyan L, James J, Xie C, Buckholz J, Pinney S . Association of systemic lupus erythematosus with uranium exposure in a community living near a uranium-processing plant: a nested case-control study. Arthritis Rheumatol. 2014; 66(11):3105-12. PMC: 4211941. DOI: 10.1002/art.38786. View

15.

Rubin R . Drug-induced lupus. Expert Opin Drug Saf. 2015; 14(3):361-78. DOI: 10.1517/14740338.2015.995089. View

16.

Pollard K . Environment, autoantibodies, and autoimmunity. Front Immunol. 2015; 6:60. PMC: 4324151. DOI: 10.3389/fimmu.2015.00060. View

17.

Cooper K, Dashner E, Tsosie R, Cho Y, Lewis J, Hudson L . Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium. Toxicol Appl Pharmacol. 2015; 291:13-20. PMC: 4718819. DOI: 10.1016/j.taap.2015.11.017. View

18.

Harmon M, Campen M, Miller C, Shuey C, Cajero M, Lucas S . Associations of Circulating Oxidized LDL and Conventional Biomarkers of Cardiovascular Disease in a Cross-Sectional Study of the Navajo Population. PLoS One. 2016; 11(3):e0143102. PMC: 4777541. DOI: 10.1371/journal.pone.0143102. View

19.

Chavalarias D, Wallach J, Li A, Ioannidis J . Evolution of Reporting P Values in the Biomedical Literature, 1990-2015. JAMA. 2016; 315(11):1141-8. DOI: 10.1001/jama.2016.1952. View

20.

Harmon M, Lewis J, Miller C, Hoover J, Ali A, Shuey C . Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities. J Expo Sci Environ Epidemiol. 2017; 27(4):365-371. PMC: 5781233. DOI: 10.1038/jes.2016.79. View