Microbiome Diurnal Rhythmicity and Its Impact on Host Physiology and Disease Risk

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2019 Mar 17

PMID 30877136

Citations 35

Authors

Samuel Philip Nobs

Timur Tuganbaev

Eran Elinav

Affiliations

Soon will be listed here.

Abstract

Host-microbiome interactions constitute key determinants of host physiology, while their dysregulation is implicated in a wide range of human diseases. The microbiome undergoes diurnal variation in composition and function, and this in turn drives oscillations in host gene expression and functions. In this review, we discuss the newest developments in understanding circadian host-microbiome interplays, and how they may be relevant in health and disease contexts. We summarize the molecular mechanisms by which the microbiome influences host function in a diurnal manner, and inversely describe how the host orchestrates circadian rhythmicity of the microbiome. Furthermore, we highlight the future perspectives and challenges in studying this new and exciting facet of host-microbiome interactions. Finally, we illustrate how the elucidation of the microbiome chronobiology may pave the way for novel therapeutic approaches.

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