Exploiting the Message from Cancer: the Diagnostic Value of Extracellular Vesicles for Clinical Applications

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2019 Mar 16

PMID 30872565

Citations 63

Authors

Nobuyoshi Kosaka

Akiko Kogure

Tomofumi Yamamoto

Fumihiko Urabe

Wataru Usuba

Marta Prieto-Vila

Takahiro Ochiya

Affiliations

Soon will be listed here.

Abstract

Liquid biopsy is indispensable for the resolution of current medical issues, such as the cost of developing new drugs and predicting responses of patients to drugs. In this sense, not only the technology for liquid biopsy but also the target biomolecules for biomarkers need to be identified. Extracellular vesicles (EVs), which contain various proteins, including membrane-bound proteins, and RNAs, including mRNA and long/short noncoding RNAs, have emerged as ideal targets for liquid biopsy. These complex biomolecules are covered by a lipid bilayer, which can protect them from degradation. In this review, we review current topics regarding EVs as cancer biomarkers and introduce technologies used for these recently emerged biomolecules.

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