Identification of a Novel Biomarker-CCL5 Using Antibody Microarray for Colorectal Cancer

Overview

Journal Pathol Res Pract

Specialty Pathology

Date 2019 Mar 16

PMID 30871911

Citations 7

Authors

Mingxia Chen

Xiaoqing Yang

Min Yang

Wei Zhang

Lei Li

Qing Sun

Affiliations

Soon will be listed here.

Abstract

Purpose: To screen novel candidate biomarkers in primary colorectal cancer (CRC), and indentify their clinical valuation in progress of colorectal cancer.

Methods: By using antibody microarray, 274 target proteins in tissue samples from primary colorectal cancer patients were detected. Among differently expressed proteins in CRC tissues, As promising candidate biomarker, RANTES/CCL5 was validated by enzyme-linked immunosorbentassay and immunohistochemistry (IHC), and the clinical significance of CCL5 was analyzed.

Results: Totally, 25 differentially expressed proteins were indentified between colorectal cancers and matched normal mucosa. CCL5 expression was significantly associated with adverse pathological progress, apt to lymph node metastasis and higher T stage.

Conclusions: CCL5 may contribute to promoting tumor growth, and CCL5 is a promising target that may help in understanding the pathogenesis of CRC.

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