Squamous Cell Carcinoma Transformation in Mature Cystic Teratoma of the Ovary: a Systematic Review

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2019 Mar 15

PMID 30866852

Citations 34

Authors

Congcong Li

Qing Zhang

Siying Zhang

Ruifen Dong

Chenggong Sun

Chunping Qiu

Zhiwei Zhang

Xingsheng Yang

Beihua Kong

Affiliations

Soon will be listed here.

Abstract

Background: 0.17-2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics and treatment of SCC transformation in MCTO METHODS: We systematically searched PubMed database and individual patient data about SCC transformation in MCTO were extracted. The published cases were combined with 6 cases of SCC transformation in MCTO from Qilu Hospital, Shandong University.

Results: The incidence of SCC transformation in MCTO was 0.3%. A total of 435 cases of SCC transformation in MCTO were enrolled in the analysis. The mean age of diagnosis was 53.5 (range 19-87) years old. The most common clinical manifestations were abdominal pain (47.3%) and abdominal mass (26.0%). StageI,II, III and IV accounted for 50.0, 18.8, 26.8 and 4.4% of all cases, respectively. Patients with stage I had significantly better prognosis than stage II, III and IV patients (P < 0.01). Hysterectomy can improve overall survival (P < 0.01). For patients younger than 45 years old with stageIA orIC, there was no difference in mortality between fertility-sparing and radical surgery (P = 1.00). Adjuvant chemotherapy can improve survival in patients with advanced stage (P = 0.02), and chemotherapy with platinum was related to better prognosis (P = 0.02).

Conclusion: SCC transformation in MCTO is a rare malignancy mainly occurs in older age. FIGO stage is an independent prognostic factor. Hysterectomy and platinum-based chemotherapy are associated with better survival. Fertility-sparing surgery is feasible for young patients with early stage.

Citing Articles

Squamous Cell Carcinoma Originating From Mature Cystic Teratoma of the Ovary Diagnosed 10 Years After Initial Tumor Detection: A Case Report.

Ohira S, Kitano R, Yokoi Y, Kitamura F, Hayashi A Cureus. 2025; 16(12):e76470.

PMID: 39867042 PMC: 11769704. DOI: 10.7759/cureus.76470.

Ruptured Ovarian Mature Cystic Teratoma with Adenocarcinoma Transformation: A Case Report.

Xu L, Jiang J, Geng Q, Zhang Y Int J Womens Health. 2024; 16:2281-2285.

PMID: 39726691 PMC: 11669543. DOI: 10.2147/IJWH.S490109.

Molecular characterization of ovarian squamous cell carcinoma originating from mature teratoma.

Chao A, Lai C, Chao A, Lin C, Wang Y, Huang H J Mol Med (Berl). 2024; 103(1):101-111.

PMID: 39630279 DOI: 10.1007/s00109-024-02505-w.

Malignant Transformation in a Mature Cystic Teratoma of the Ovary: A 5-year Descriptive Study.

Billod J, Manangan-Wong R Acta Med Philipp. 2024; 58(15):55-60.

PMID: 39308880 PMC: 11413461. DOI: 10.47895/amp.vi0.8023.

Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A case report.

Xu G, Xu C, Yang L SAGE Open Med Case Rep. 2024; 12:2050313X241272650.

PMID: 39165301 PMC: 11334125. DOI: 10.1177/2050313X241272650.

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