Diabetes Alters Drug Metabolism--in Vivo Studies in a Streptozotozin-diabetic Rat Model

Overview

Journal Experientia

Specialty Science

Date 1986 May 15

PMID 3086116

Citations 4

Authors

T Zysset

L Sommer

Affiliations

Soon will be listed here.

Abstract

The influence of experimental streptozotozin-induced diabetes on hepatic drug metabolism in vivo has been studied in rats, using 14CO2-exhalation after 14C-aminopyrine injection. Male diabetic rats showed a decreased (-18%), females an increased (+19%) 14CO2-exhalation compared to controls, indicating altered hepatic drug metabolism due to diabetes.

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References

Past M, Cook D . Effect of diabetes on rat liver cytochrome P-450. Evidence for a unique diabetes-dependent rat liver cytochrome P-450. Biochem Pharmacol. 1982; 31(20):3329-34. DOI: 10.1016/0006-2952(82)90569-x. View

Stohs S, Roche E . Altered metabolism of 7-ethoxycoumarin by hepatic, pulmonary, and intestinal microsomes from streptozotocin-diabetic rats. Drug Metab Dispos. 1980; 8(1):44-5. View

Thurman R, Marazzo D, Jones L, Kauffman F . The continuous kinetic determination of p-nitroanisole O-demethylation in hemoglobin-free perfused rat liver. J Pharmacol Exp Ther. 1977; 201(2):498-506. View

Cook D, Past M . Drug metabolism in diabetic isolated perfused rat liver. Res Commun Chem Pathol Pharmacol. 1979; 24(2):389-92. View

WINCHELL H, STAHELIN H, Kusubov N, Slanger B, Fish M, POLLYCOVE M . Kinetics of CO2-HCO3 minus in normal adult males. J Nucl Med. 1970; 11(12):711-5. View

Past M, Cook D, HOFERT J . Effect of adrenalectomy on the cytochrome P-450 population of diabetic rat liver. Horm Metab Res. 1983; 15(6):306. DOI: 10.1055/s-2007-1018702. View

Lauterburg B, BIRCHER J . Expiratory measurement of maximal amino-pyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, protacaval shunt and bile duct ligation in the rat. J Pharmacol Exp Ther. 1976; 196(2):501-9. View

Slanger B, Kusubov N, WINCHELL H . Effect of exercise on human CO2-HCO3 minus kinetics. J Nucl Med. 1970; 11(12):716-8. View

Baker A, Kotake A, Schoeller D . Clinical utility of breath tests for the assessment of hepatic function. Semin Liver Dis. 1983; 3(4):318-29. DOI: 10.1055/s-2008-1040784. View

10.

Stohs S, Roche E . Activities of hepatic and extrahepatic microsomal mixed function oxidase enzymes in diabetic and gonadectomized-diabetic rats. Gen Pharmacol. 1981; 12(5):345-50. DOI: 10.1016/0306-3623(81)90088-4. View

11.

Eacho P, Weiner M . Metabolism of p-nitroanisole and aniline in isolated hepatocytes of streptozotocin-diabetic rats. Drug Metab Dispos. 1980; 8(6):385-9. View

12.

Past M, Cook D . Absence of cytosol effects on the rates of microsomal drug metabolism in alloxan and streptozotocin diabetic rats. Biochem Pharmacol. 1980; 29(18):2499-503. DOI: 10.1016/0006-2952(80)90355-x. View

13.

Past M, Cook D . Alterations in hepatic microsomal cytochrome P-450 hemeproteins in diabetic rats. Res Commun Chem Pathol Pharmacol. 1980; 27(2):329-37. View

14.

Irving C, Schoeller D, Nakamura K, Baker A, KLEIN P . The aminopyrine breath test as a measure of liver function. A quantitative description of its metabolic basis in normal subjects. J Lab Clin Med. 1982; 100(3):356-73. View

15.

Eacho P, Sweeny D, Weiner M . Conjugation of p-nitroanisole and p-nitrophenol in hepatocytes isolated from streptozotocin diabetic rats. J Pharmacol Exp Ther. 1981; 218(1):34-40. View

16.

Warren B, Pak R, Finlayson M, Gontovnick L, Sunahara G, Bellward G . Differential effects of diabetes on microsomal metabolism of various substrates. Comparison of streptozotocin and spontaneously diabetic Wistar rats. Biochem Pharmacol. 1983; 32(2):327-35. DOI: 10.1016/0006-2952(83)90563-4. View

17.

Kato R, GILLETTE J . Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes. J Pharmacol Exp Ther. 1965; 150(2):285-91. View

18.

Skett P, Joels L . Different effects of acute and chronic diabetes mellitus on hepatic drug metabolism in the rat. Biochem Pharmacol. 1985; 34(2):287-9. DOI: 10.1016/0006-2952(85)90139-x. View

19.

Faas F, Carter W . Cytochrome P450 mediated drug metabolism in the streptozotocin diabetic rat. Horm Metab Res. 1980; 12(12):706-7. DOI: 10.1055/s-2007-999239. View

20.

Reinke L, Stohs S, Rosenberg H . Altered activity of hepatic mixed-function mono-oxygenase enzymes in streptozotocin-induced diabetic rats. Xenobiotica. 1978; 8(10):611-9. DOI: 10.3109/00498257809069573. View