Bilateral Trial Vocal Fold Injection with Hyaluronic Acid in Patients with Vocal Fold Atrophy with or Without Sulcus

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2019 Mar 13

PMID 30859293

Citations 7

Authors

Emke M J M van den Broek

Bas J Heijnen

Martine Hendriksma

Antonius P M Langeveld

Peter Paul G van Benthem

Elisabeth V Sjogren

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the outcome of bilateral trial vocal fold injection (VFI) with hyaluronic acid in patients with vocal fold atrophy ± sulcus and to assess the predictive value of trial VFI on the outcome of durable medialization procedure.

Methods: Voice data collected according to a standardized protocol before and one month after trial VFI of 68 patients with vocal fold atrophy (30) and atrophy with sulcus (38) were analyzed. Voice Handicap Index (VHI)-30 was compared to the outcome of a durable medialization at 3 and 12 months.

Results: The overall VHI-30 improvement was 16.8 points (from 49.9 to 33.1), which was statistically significant and clinically relevant. 57.8% of the patients experienced enough subjective benefit after trial VFI to undergo durable medialization. Of the patients that experienced subjective benefit 62% had a clinically relevant improvement in VHI-30. There was no relevant change in other parameters and no difference between ± sulcus. After durable medialization 90-94% of the patients had VHI-30 scores similar to or better than post-trial VFI.

Conclusion: The majority of patients experience subjective improvement after bilateral trial VFI indicating that medialization is a valid treatment option for patients with vocal fold atrophy ± sulcus. The VHI-30 only partially overlaps with patients' subjective evaluation and does not predict which patients will experience subjective improvement. It is, however, predictive for VHI-30 outcome after durable medialization. The aerodynamic and acoustic parameters showed no relevant change. Further identification of voice assessment parameters accurately reflecting the subjective experience of these patients is warranted.

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Glottic insufficiency caused by vocal fold atrophy with or without sulcus: systematic review of outcome measurements.

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