Haemolysis in Sickle Cell Anaemia: Effects of Polymorphisms in α-globin Gene Regulatory Elements

Overview

Journal Br J Haematol

Specialty Hematology

Date 2019 Mar 12

PMID 30854637

Citations 3

Authors

Jacqueline N Milton

Elmutaz M Shaikho

Martin H Steinberg

Affiliations

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Citing Articles

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.

Kirkham J, Estepp J, Weiss M, Rashkin S JAMA Netw Open. 2023; 6(10):e2337484.

PMID: 37851445 PMC: 10585422. DOI: 10.1001/jamanetworkopen.2023.37484.

Effects of Senegal haplotype (-rs7412844), alpha-thalassemia (3.7kb deletion), -rs11248850 and -rs4671393 variants on sickle cell nephropathy.

Ndour E, Mnika K, Tall F, Seck M, Ly I, Nembaware V Int J Biochem Mol Biol. 2022; 13(2):5-16.

PMID: 35611053 PMC: 9123508.

Sickle cell disease in the era of precision medicine: looking to the future.

Steinberg M, Kumar S, Murphy G, Vanuytsel K Expert Rev Precis Med Drug Dev. 2020; 4(6):357-367.

PMID: 33015364 PMC: 7531762. DOI: 10.1080/23808993.2019.1688658.

References

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Steinberg M, Sebastiani P . Genetic modifiers of sickle cell disease. Am J Hematol. 2012; 87(8):795-803. PMC: 4562292. DOI: 10.1002/ajh.23232. View

Nouraie M, Lee J, Zhang Y, Kanias T, Zhao X, Xiong Z . The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 2012; 98(3):464-72. PMC: 3659937. DOI: 10.3324/haematol.2012.068965. View

Milton J, Rooks H, Drasar E, McCabe E, Baldwin C, Melista E . Genetic determinants of haemolysis in sickle cell anaemia. Br J Haematol. 2013; 161(2):270-8. PMC: 4129543. DOI: 10.1111/bjh.12245. View

Hay D, Hughes J, Babbs C, Davies J, Graham B, Hanssen L . Genetic dissection of the α-globin super-enhancer in vivo. Nat Genet. 2016; 48(8):895-903. PMC: 5058437. DOI: 10.1038/ng.3605. View