Molecular Mechanisms of Coupling to Voltage Sensors in Voltage-evoked Cellular Signals

Overview

Journal Proc Jpn Acad Ser B Phys Biol Sci

Specialties Biology
Science

Date 2019 Mar 12

PMID 30853698

Citations 6

Authors

Yasushi Okamura

Yoshifumi Okochi

Affiliations

Soon will be listed here.

Abstract

The voltage sensor domain (VSD) has long been studied as a unique domain intrinsic to voltage-gated ion channels (VGICs). Within VGICs, the VSD is tightly coupled to the pore-gate domain (PGD) in diverse ways suitable for its specific function in each physiological context, including action potential generation, muscle contraction and relaxation, hormone and neurotransmitter secretion, and cardiac pacemaking. However, some VSD-containing proteins lack a PGD. Voltage-sensing phosphatase contains a cytoplasmic phosphoinositide phosphatase with similarity to phosphatase and tensin homolog (PTEN). H1, a voltage-gated proton channel, also lacks a PGD. Within H1, the VSD operates as a voltage sensor, gate, and pore for both proton sensing and permeation. H1 has a C-terminal coiled coil that mediates dimerization for cooperative gating. Recent progress in the structural biology of VGICs and VSD proteins provides insights into the principles of VSD coupling conserved among these proteins as well as the hierarchy of protein organization for voltage-evoked cell signaling.

Citing Articles

Dimerization is required for the glycosylation of S1-S2 linker of sea urchin voltage-gated proton channel Hv1.

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Protons in Gating the Kv1.2 Channel: A Calculated Set of Protonation States in Response to Polarization/Depolarization of the Channel, with the Complete Proposed Proton Path from Voltage Sensing Domain to Gate.

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PMID: 35877921 PMC: 9318985. DOI: 10.3390/membranes12070718.

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