Ghrelin Regulation of Glucose Metabolism

Overview

Journal J Neuroendocrinol

Specialty Endocrinology

Date 2019 Mar 9

PMID 30849212

Citations 23

Authors

Sarah M Gray

Laura C Page

Jenny Tong

Affiliations

Soon will be listed here.

Abstract

Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are implicated in the regulation of glucose metabolism via direct actions in the pancreatic islet, as well as peripheral insulin-sensitive tissues and the brain. Although many studies have explored the role of ghrelin in glucose tolerance and insulin secretion, a complete mechanistic understanding remains to be clarified. This review highlights the local expression and function of ghrelin and GHSR1a in pancreatic islets and how this axis may modulate insulin secretion from pancreatic β-cells. Additionally, we discuss the effect of ghrelin on in vivo glucose metabolism in rodents and humans, as well as the metabolic circumstances under which the action of ghrelin may predominate.

Citing Articles

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Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?.

Mingardi J, Meanti R, Paoli C, Cifani C, Torsello A, Popoli M Curr Neuropharmacol. 2024; 23(2):172-186.

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Correlation analysis between the changes in plasma ghrelin level and weight loss after sleeve gastrectomy combined with fundoplication.

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The role of central neurotransmitters in appetite regulation of broilers and layers: similarities and differences.

Mahdavi K, Zendehdel M, Zarei H Vet Res Commun. 2024; 48(3):1313-1328.

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Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner.

Andreoli M, Fittipaldi A, Castrogiovanni D, De Francesco P, Valdivia S, Heredia F Eur J Nutr. 2023; 63(3):751-762.

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