Precision Medicine for Frontotemporal Dementia

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2019 Mar 9

PMID 30846947

Citations 8

Authors

Mu-N Liu

Chi-Ieong Lau

Ching-Po Lin

Affiliations

Soon will be listed here.

Abstract

Frontotemporal dementia (FTD) is a common young-onset dementia presenting with heterogeneous and distinct syndromes. It is characterized by progressive deficits in behavior, language, and executive function. The disease may exhibit similar characteristics to many psychiatric disorders owing to its prominent behavioral features. The concept of precision medicine has recently emerged, and it involves neurodegenerative disease treatment that is personalized to match an individual's specific pattern of neuroimaging, neuropathology, and genetic variability. In this paper, the pathophysiology underlying FTD, which is characterized by the selective degeneration of the frontal and temporal cortices, is reviewed. We also discuss recent advancements in FTD research from the perspectives of clinical, imaging, molecular characterizations, and treatment. This review focuses on the approach of precision medicine to manage the clinical and biological complexities of FTD.

Citing Articles

miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia.

Manzini V, Cappelletti P, Orefice N, Brentari I, Rigby M, Lo Giudice M Mol Neurobiol. 2024; 62(2):2573-2586.

PMID: 39138758 PMC: 11772464. DOI: 10.1007/s12035-024-04386-z.

Abnormalities of Hippocampal Subfield and Amygdalar Nuclei Volumes and Clinical Correlates in Behavioral Variant Frontotemporal Dementia with Obsessive-Compulsive Behavior-A Pilot Study.

Liu M, Hu L, Tsai C, Hong C, Chou Y, Chang C Brain Sci. 2023; 13(11).

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Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes.

Pacheco Pachado M, Casas A, Elbatreek M, Nogales C, Guney E, Espay A J Alzheimers Dis. 2023; 96(1):47-56.

PMID: 37742653 PMC: 10657714. DOI: 10.3233/JAD-230694.

Early-stage differentiation between Alzheimer's disease and frontotemporal lobe degeneration: Clinical, neuropsychology, and neuroimaging features.

Li P, Quan W, Wang Z, Liu Y, Cai H, Chen Y Front Aging Neurosci. 2022; 14:981451.

PMID: 36389060 PMC: 9659748. DOI: 10.3389/fnagi.2022.981451.

An Indonesian elderly with primary progressive aphasia and behavioral variant of frontotemporal dementia: A case report and review article.

Riswanto A, Sihombing W, Haryono Y Ann Med Surg (Lond). 2022; 81:104545.

PMID: 36147075 PMC: 9486748. DOI: 10.1016/j.amsu.2022.104545.

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