Effects of Low-level Microwave Irradiation on Amphetamine Hyperthermia Are Blockable by Naloxone and Classically Conditionable

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1986 Jan 1

PMID 3083456

Authors

H Lai

A Horita

C K Chou

A W Guy

Affiliations

Soon will be listed here.

Abstract

In a series of experiments, we investigated the effects of pulsed low-level microwave irradiation on amphetamine-induced hyperthermia in the rat. Rats were irradiated in a 2,450-MHz cylindrical waveguide exposure system at 1 mW/cm2, 2 mus pulses, 500 pps, average SAR of 0.6 W/kg. Acute (45 min) exposure to microwaves attenuated amphetamine-induced hyperthermia. This effect was blocked by pretreatment of the animals with the narcotic antagonist naloxone. In another experiment, rats were subjected to ten daily sessions of microwave exposure (45 min/session). On day 11, amphetamine-induced hyperthermia was studied in the animals immediately after a session of either microwave or sham exposure. Similar to the acute effect, amphetamine-induced hyperthermia was attenuated in rats irradiated with microwaves (unconditioned effect). In the sham-irradiated animals we observed a potentiation of the amphetamine-induced hyperthermia, which was a conditioned effect of microwaves. Thus, the conditioned effect (potentiation) was opposite in direction to the unconditioned effect (attenuation). No tolerance developed to the unconditioned effect after subchronic exposure. Furthermore, both conditioned and unconditioned effects of microwaves on amphetamine-induced hyperthermia could be blocked by treatment with naloxone. These data suggest that microwave irradiation may activate endogenous opioids, which in turn alter the actions of psychoactive drugs, and the effect of microwaves on drug action can be classically conditioned.

References

Siegel S, Hinson R, Krank M, McCully J . Heroin "overdose" death: contribution of drug-associated environmental cues. Science. 1982; 216(4544):436-7. DOI: 10.1126/science.7200260. View

Millan M, Duka T . Anxiolytic properties of opiates and endogenous opioid peptides and their relationship to the actions of benzodiazepines. Mod Probl Pharmacopsychiatry. 1981; 17:123-41. DOI: 10.1159/000402410. View

Chance W, White A, Krynock G, Rosencrans J . Conditional fear-induced antinociception and decreased binding of [3H]N-leu-enkephalin to rat brain. Brain Res. 1978; 141(2):371-4. DOI: 10.1016/0006-8993(78)90208-1. View

Esposito R, Perry W, KORNETSKY C . Effects of d-amphetamine and naloxone on brain stimulation reward. Psychopharmacology (Berl). 1980; 69(2):187-91. DOI: 10.1007/BF00427648. View

Lai H, Horita A, Chou C, Guy A . Effects of acute low-level microwaves on pentobarbital-induced hypothermia depend on exposure orientation. Bioelectromagnetics. 1984; 5(2):203-11. DOI: 10.1002/bem.2250050208. View

Millan M . Stress and endogenous opioid peptides: a review. Mod Probl Pharmacopsychiatry. 1981; 17:49-67. DOI: 10.1159/000402406. View

BARANSKI S, EDELWEJN Z . [Studies on the combined effect of microwaves and some drugs on the bioelectric activity of the central nervous system in rabbits]. Acta Physiol Pol. 1968; 19(1):37-50. View

Stern S . Behavioral effects of microwaves. Neurobehav Toxicol. 1980; 2(1):49-58. View

Drawbaugh R, Lal H . Effect of pharmacological interference with various neuropathways on blockade of morphine-withdrawal hypothermia by morphine and by conditional stimulus. Neuropharmacology. 1976; 15(6):375-8. DOI: 10.1016/0028-3908(76)90087-3. View

10.

Rossier J, Guillemin R, BLOOM F . Foot shock induced stress decreases leu5-enkephalin immunoreactivity in rat hypothalamus. Eur J Pharmacol. 1978; 48(4):465-6. DOI: 10.1016/0014-2999(78)90178-4. View

11.

Clark W . Effects of opioid peptides on thermoregulation. Fed Proc. 1981; 40(13):2754-9. View

12.

Woods S, Makous W, HUTTON R . Temporal parameters of conditioned hypoglycemia. J Comp Physiol Psychol. 1969; 69(2):301-7. DOI: 10.1037/h0028186. View

13.

Amir S, Brown Z, Amit Z . The role of endorphins in stress: evidence and speculations. Neurosci Biobehav Rev. 1980; 4(1):77-86. DOI: 10.1016/0149-7634(80)90027-5. View

14.

Siegel S . Morphine tolerance acquisition as an associative process. J Exp Psychol Anim Behav Process. 1977; 3(1):1-13. DOI: 10.1037//0097-7403.3.1.1. View

15.

Le A, Poulos C, Cappell H . Conditioned tolerance to the hypothermic effect of ethyl alcohol. Science. 1979; 206(4422):1109-10. DOI: 10.1126/science.493999. View

16.

MAYNERT E, KLINGMAN G . Tolerance to morphine. I. Effects on catecholamines in the brain and adrenal glands. J Pharmacol Exp Ther. 1962; 135:285-95. View

17.

Dettmar P, Cowan A, Walter D . Naloxone antagonizes behavioural effects of d-amphetamine in mice and rats. Neuropharmacology. 1978; 17(12):1041-4. DOI: 10.1016/0028-3908(78)90031-x. View

18.

Roffman M, Reddy C, Lal H . Control of morphine-withdrawal hypothermia by conditional stimuli. Psychopharmacologia. 1973; 29(3):197-201. DOI: 10.1007/BF00414033. View

19.

Wangemann R, Cleary S . The in vivo effects of 2.45 GHz microwave radiation of rabbit serum components and sleeping times. Radiat Environ Biophys. 1976; 13(2):89-103. DOI: 10.1007/BF01332170. View

20.

Pae Y, Lai H, Horita A . Hyperthermia in the rat from handling stress blocked by naltrexone injected into the preoptic-anterior hypothalamus. Pharmacol Biochem Behav. 1985; 22(2):337-9. DOI: 10.1016/0091-3057(85)90400-9. View