Rise of the Visible Monkey: Sectioned Images of Rhesus Monkey

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2019 Mar 6

PMID 30833883

Citations 6

Authors

Beom Sun Chung

Chang-Yeop Jeon

Jae-Won Huh

Kang-Jin Jeong

Donghwan Har

Kyu-Sung Kwack

Jin Seo Park

Affiliations

Soon will be listed here.

Abstract

Background: Gross anatomy and sectional anatomy of a monkey should be known by students and researchers of veterinary medicine and medical research. However, materials to learn the anatomy of a monkey are scarce. Thus, the objective of this study was to produce a Visible Monkey data set containing cross sectional images, computed tomographs (CTs), and magnetic resonance images (MRIs) of a monkey whole body.

Methods: Before and after sacrifice, a female rhesus monkey was used for 3 Tesla MRI and CT scanning. The monkey was frozen and sectioned at 0.05 mm intervals for the head region and at 0.5 mm intervals for the rest of the body using a cryomacrotome. Each sectioned surface was photographed using a digital camera to obtain horizontal sectioned images. Segmentation of sectioned images was performed to elaborate three-dimensional (3D) models of the skin and brain.

Results: A total of 1,612 horizontal sectioned images of the head and 1,355 images of the remaining region were obtained. The small pixel size (0.024 mm × 0.024 mm) and real color (48 bits color) of these images enabled observations of minute structures.

Conclusion: Due to small intervals of these images, continuous structures could be traced completely. Moreover, 3D models of the skin and brain could be used for virtual dissections. Sectioned images of this study will enhance the understanding of monkey anatomy and foster further studies. These images will be provided to any requesting researcher free of charge.

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References

Schiemann T, Freudenberg J, Pflesser B, Pommert A, Priesmeyer K, Riemer M . Exploring the Visible Human using the VOXEL-MAN framework. Comput Med Imaging Graph. 2000; 24(3):127-32. DOI: 10.1016/s0895-6111(00)00013-6. View

Park J, Chung M, Hwang S, Lee Y, Har D, Park H . Visible Korean human: improved serially sectioned images of the entire body. IEEE Trans Med Imaging. 2005; 24(3):352-60. DOI: 10.1109/tmi.2004.842454. View

Teran J, Sifakis E, Blemker S, Ng-Thow-Hing V, Lau C, Fedkiw R . Creating and simulating skeletal muscle from the visible human data set. IEEE Trans Vis Comput Graph. 2005; 11(3):317-28. DOI: 10.1109/TVCG.2005.42. View

Croxson P, Johansen-Berg H, Behrens T, Robson M, Pinsk M, Gross C . Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography. J Neurosci. 2005; 25(39):8854-66. PMC: 6725599. DOI: 10.1523/JNEUROSCI.1311-05.2005. View

Zhang S, Heng P, Liu Z . Chinese visible human project. Clin Anat. 2006; 19(3):204-15. DOI: 10.1002/ca.20273. View

Wisco J, Killiany R, Guttmann C, Warfield S, Moss M, Rosene D . An MRI study of age-related white and gray matter volume changes in the rhesus monkey. Neurobiol Aging. 2007; 29(10):1563-75. PMC: 2605721. DOI: 10.1016/j.neurobiolaging.2007.03.022. View

Vincent J, Patel G, Fox M, Snyder A, Baker J, Van Essen D . Intrinsic functional architecture in the anaesthetized monkey brain. Nature. 2007; 447(7140):83-6. DOI: 10.1038/nature05758. View

Zhang G, Luo Q, Zeng S, Liu Q . The development and application of the visible Chinese human model for Monte Carlo dose calculations. Health Phys. 2008; 94(2):118-25. DOI: 10.1097/01.HP.0000285256.48498.b4. View

McLaren D, Kosmatka K, Oakes T, Kroenke C, Kohama S, Matochik J . A population-average MRI-based atlas collection of the rhesus macaque. Neuroimage. 2008; 45(1):52-9. PMC: 2659879. DOI: 10.1016/j.neuroimage.2008.10.058. View

10.

Park J, Chung M, Park H, Shin D, Har D, Cho Z . A proposal of new reference system for the standard axial, sagittal, coronal planes of brain based on the serially-sectioned images. J Korean Med Sci. 2010; 25(1):135-41. PMC: 2800020. DOI: 10.3346/jkms.2010.25.1.135. View

11.

Kilkenny C, Browne W, Cuthill I, Emerson M, Altman D . Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol. 2010; 160(7):1577-9. PMC: 2936830. DOI: 10.1111/j.1476-5381.2010.00872.x. View

12.

Jing W, Wenchao W, Lin L, Li L, Guimei W, Heng T . A new MRI approach for accurately implanting microelectrodes into deep brain structures of the rhesus monkey (Macaca mulatta). J Neurosci Methods. 2010; 193(2):203-9. DOI: 10.1016/j.jneumeth.2010.07.039. View

13.

Frey S, Pandya D, Chakravarty M, Bailey L, Petrides M, Collins D . An MRI based average macaque monkey stereotaxic atlas and space (MNI monkey space). Neuroimage. 2011; 55(4):1435-42. DOI: 10.1016/j.neuroimage.2011.01.040. View

14.

Mars R, Jbabdi S, Sallet J, OReilly J, Croxson P, Olivier E . Diffusion-weighted imaging tractography-based parcellation of the human parietal cortex and comparison with human and macaque resting-state functional connectivity. J Neurosci. 2011; 31(11):4087-100. PMC: 3091022. DOI: 10.1523/JNEUROSCI.5102-10.2011. View

15.

Li T, Gong H, Luo Q . Visualization of light propagation in visible Chinese human head for functional near-infrared spectroscopy. J Biomed Opt. 2011; 16(4):045001. DOI: 10.1117/1.3567085. View

16.

McBride J, Pitzer M, Boudreau R, Dufour B, Hobbs T, Ojeda S . Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease. Mol Ther. 2011; 19(12):2152-62. PMC: 3242667. DOI: 10.1038/mt.2011.219. View

17.

Shin D, Chung M, Park H, Park J, Hwang S . Browsing software of the Visible Korean data used for teaching sectional anatomy. Anat Sci Educ. 2011; 4(6):327-32. DOI: 10.1002/ase.249. View

18.

Dai J, Chung M, Qu R, Yuan L, Liu S, Shin D . The Visible Human Projects in Korea and China with improved images and diverse applications. Surg Radiol Anat. 2012; 34(6):527-34. DOI: 10.1007/s00276-012-0945-8. View

19.

McDannold N, Arvanitis C, Vykhodtseva N, Livingstone M . Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res. 2012; 72(14):3652-63. PMC: 3533365. DOI: 10.1158/0008-5472.CAN-12-0128. View

20.

Shin D, Chung M, Park J, Park H, Lee S, Moon Y . Portable document format file showing the surface models of cadaver whole body. J Korean Med Sci. 2012; 27(8):849-56. PMC: 3410230. DOI: 10.3346/jkms.2012.27.8.849. View