Tumor-educated Platelets

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2019 Mar 6

PMID 30833413

Citations 85

Authors

Sjors G J G In t Veld

Thomas Wurdinger

Affiliations

Soon will be listed here.

Abstract

Liquid biopsies have been considered the holy grail in achieving effective cancer management, with blood tests offering a minimally invasive, safe, and sensitive alternative or complementary approach for tissue biopsies. Currently, blood-based liquid biopsy measurements focus on the evaluation of biomarker types, including circulating tumor DNA, circulating tumor cells, extracellular vesicles (exosomes and oncosomes), and tumor-educated platelets (TEPs). Despite the potential of individual techniques, each has its own advantages and disadvantages. Here, we provide further insight into TEPs.

Citing Articles

Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. "Re-discovering the neglected biosources of the liquid biopsy family".

Gottardo A, Gristina V, Perez A, Di Giovanni E, Contino S, Barraco N J Liq Biopsy. 2025; 3:100136.

PMID: 40026563 PMC: 11863699. DOI: 10.1016/j.jlb.2024.100136.

The role of platelets in cancer: from their influence on tumor progression to their potential use in liquid biopsy.

Morales-Pacheco M, Valenzuela-Mayen M, Gonzalez-Alatriste A, Mendoza-Almanza G, Cortes-Ramirez S, Losada-Garcia A Biomark Res. 2025; 13(1):27.

PMID: 39934930 PMC: 11818056. DOI: 10.1186/s40364-025-00742-w.

Development of an accurate breast cancer detection classifier based on platelet RNA.

Xie W, Hu J, Zhao Z, Lu H, Han Y, Li B Sci Rep. 2024; 14(1):30733.

PMID: 39730431 PMC: 11680589. DOI: 10.1038/s41598-024-80175-x.

Exosomes and breast cancer angiogenesis; Highlights in intercellular communication.

Khanicheragh P, Abbasi-Malati Z, Saghebasl S, Hassanpour P, Milani S, Rahbarghazi R Cancer Cell Int. 2024; 24(1):402.

PMID: 39696346 PMC: 11656829. DOI: 10.1186/s12935-024-03606-9.

Comprehensive Analysis of a Platelet- and Coagulation-Related Prognostic Gene Signature Identifies CYP19A1 as a Key Tumorigenic Driver of Colorectal Cancer.

Su G, Wang M, Qian J, Wang Y, Zhu Y, Wang N Biomedicines. 2024; 12(10).

PMID: 39457539 PMC: 11505370. DOI: 10.3390/biomedicines12102225.