Pediatric Drug Hypersensitivity: Which Diagnostic Tests?

Overview

Journal Acta Biomed

Specialty General Medicine

Date 2019 Mar 5

PMID 30830067

Citations 1

Authors

Francesca Saretta

Francesca Mori

Fabio Cardinale

Lucia Liotti

Fabrizio Franceschini

Giuseppe Crisafulli

Silvia Caimmi

Paolo Bottau

Roberto Bernardini

Carlo Caffarelli

Affiliations

Soon will be listed here.

Abstract

Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled. Only a few published studies evaluated sensitivity and specificity of skin and in vitro tests in children. However, selected case series show that diagnostic work-up for adults could be useful, with some limitations, in pediatric age. Indeed, despite improvement in in vivo and in vitro diagnosis, drug provocation test remains the gold standard in pediatric age, too. Unmet needs in children include multi-centric studies on incidence of DHR, utility and feasibility of in vivo and in vitro diagnostic tests and specifically dedicated guidelines for the diagnosis and management of DHR in children.

Citing Articles

Drug Allergy in Children: What Should We Know?.

Park J, Suh D Clin Exp Pediatr. 2020; 63(6):203-210.

PMID: 32024327 PMC: 7303428. DOI: 10.3345/kjp.2019.00675.

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