Allergic Reactions to Cow's Milk Proteins in Medications in Childhood

Overview

Journal Acta Biomed

Specialty General Medicine

Date 2019 Mar 5

PMID 30830066

Citations 9

Authors

Angelica Santoro

Laura Andreozzi

Giampaolo Ricci

Carla Mastrorilli

Carlo Caffarelli

Affiliations

Soon will be listed here.

Abstract

Introduction: Cow's milk is a frequent trigger of allergic reactions in childhood. Cow's milk proteins can be present in pharmaceutical excipients.

Methods: We have analyzed paediatric literature on allergic reactions to cow's milk proteins in medication, focusing on the different routes of administration (inhaled, parental and oral).

Results: Dry-powder inhalers may contain lactose as excipient. Lactose can be rarely contaminated with milk proteins and it may induce allergic reactions in patients with cow's milk allergy. Case reports have described immediate hypersensitivity reactions to methylprednisolone sodium succinate 40 mg injection, a formulation that contains lactose as excipient. Some cases of anaphylaxis after receiving diphteria-tetanus-pertussis vaccine injection in children allergic to milk have been reported. Cow's milk proteins can be detected also in oral polio vaccine, certain probiotics and lactulose syrup.

Conclusions: We suggest caution in administration of pharmaceuticals containing milk allergens in children allergic to milk.

Citing Articles

Anaphylaxis to cow's milk protein in a probiotic not detected by the electronic medical record.

Teitelbaum J, Dallessio J, Brunetto J, Ross J JPGN Rep. 2024; 5(4):505-507.

PMID: 39610428 PMC: 11600377. DOI: 10.1002/jpr3.12128.

Risks of dairy derived excipients in medications for lactose intolerant and cow milk protein allergic patients.

Figueiredo A, Auxtero M, Santo M, Casimiro A, Costa I Sci Rep. 2024; 14(1):15631.

PMID: 38972872 PMC: 11228012. DOI: 10.1038/s41598-024-66380-8.

Quantitative Investigation on Exposure to Potentially Harmful Excipients by Injection Drug Administration in Children Under 2 Years of Age and Analysis of Association with Adverse Events: A Single-Center, Retrospective Observational Study.

Saito J, Nakamura H, Akabane M, Yamatani A Ther Innov Regul Sci. 2023; 58(2):316-335.

PMID: 38055156 DOI: 10.1007/s43441-023-00596-0.

Vaccine-induced anaphylaxis in a child with cow's milk allergy: Lactose hydrate was the culprit.

Yoshino S, Hiraguchi Y, Tatekawa M, Shingaki T, Kumagai Y, Ebishima Y J Allergy Clin Immunol Glob. 2023; 1(2):87-89.

PMID: 37780587 PMC: 10509965. DOI: 10.1016/j.jacig.2022.01.003.

Food allergens in oral care products.

Coimbra L, Costa I, Evangelista J, Figueiredo A Sci Rep. 2023; 13(1):6684.

PMID: 37095111 PMC: 10126110. DOI: 10.1038/s41598-023-33125-y.

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