P435 HER2/neu-derived Peptide Conjugated to Liposomes Containing DOPE As an Effective Prophylactic Vaccine Formulation for Breast Cancer

Overview

Journal Artif Cells Nanomed Biotechnol

Specialties Biomedical Engineering
Biotechnology

Date 2019 Mar 5

PMID 30829072

Citations 10

Authors

Niloofar Farzad

Nastaran Barati

Amir Abbas Momtazi-Borojeni

Mona Yazdani

Atefeh Arab

Atefeh Razazan

Sheida Shariat

Mercedeh Mansourian

Azam Abbasi

Zahra Saberi

Ali Badiee

Seyed Amir Jalali

Mahmoud Reza Jaafari

Affiliations

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Abstract

The present study was aimed to develop an effective nanoliposomal vaccine delivery system with P435 HER2/neu-derived peptide conjugated to Maleimide-PEG2000-DSPE. The nanoliposome formulation composed of DSPC/DSPG/Chol/DOPE and monophosphoryl lipid A was used as an adjuvant. Liposomal formulations were prepared and their physical properties were characterized. Anti-tumoral efficacy of formulations was evaluated by immunization of tumor-bearing BALB/c mice and the generated immune response was studied by using ELISpot and flow cytometry analysis. The results of the study demonstrated Lip + DOPE + P535 formulation caused the lowest tumor size and the longest survival time in TUBO mice model and could make it a promising candidate in developing effective vaccines against HER2-positive breast cancers.

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