Circulating Lupus Type Anticoagulant and Pulmonary Hypertension Associated with Mixed Connective Tissue Disease

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 1986 Jan 1

PMID 3082573

Citations 6

Authors

P Hainaut

E Lavenne

J M Magy

E G Lebacq

Affiliations

Soon will be listed here.

Abstract

We report the case of a young woman, with mixed connective tissue disease (MCTD), associated with disabling pulmonary hypertension and presence of the "lupus anticoagulant". The "lupus anticoagulant", an antibody directed against phospholipid components, was linked in our patient to extensive thrombophlebitis and premature labor. Raynaud's phenomenon progressed towards finger necrosis in spite of optimal vasodilating treatment. The part played by the "lupus anticoagulant" in pulmonary hypertension remains to be established. Both these complications responded to prednisolone therapy, but the improvement was limited and short-lived.

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