Expression of the Heparin-binding Growth Factors Midkine and Pleiotrophin During Ocular Development

Overview

Journal Gene Expr Patterns

Publisher Elsevier

Date 2019 Mar 3

PMID 30825522

Citations 4

Authors

Ruda Cui

Peter Lwigale

Affiliations

Soon will be listed here.

Abstract

Midkine (MDK) and Pleiotrophin (PTN) belong to a group of heparin-binding growth factors that has been shown to have pleiotropic functions in various biological processes during development and disease. Development of the vertebrate eye is a multistep process that involves coordinated interactions between neuronal and non-neuronal cells, but very little is known about the potential function of MDK and PTN in these processes. In this study, we demonstrate by section in situ hybridization, the spatiotemporal expression of MDK and PTN during ocular development in chick and mouse. We show that MDK and PTN are expressed in dynamic patterns that overlap in a few non-neuronal tissues in the anterior eye and in neuronal cell layers of the posterior eye. We show that the expression patterns of MDK and PTN are only conserved in a few tissues in chick and mouse but they overlap with the expression of some of their receptors LRP1, RPTPZ, ALK, NOTCH2, ITGβ1, SDC1, and SDC3. The dynamic expression patterns of MDK, PTN and their receptors suggest that they function together during the multistep process of ocular development and they may play important roles in cell proliferation, adhesion, and migration of neuronal and non-neuronal cells.

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References

Yang X, Tare R, Partridge K, Roach H, Clarke N, Howdle S . Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. J Bone Miner Res. 2003; 18(1):47-57. DOI: 10.1359/jbmr.2003.18.1.47. View

Qi M, Ikematsu S, Maeda N, Sakuma S, Noda M, Muramatsu T . Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase. J Biol Chem. 2001; 276(19):15868-75. DOI: 10.1074/jbc.m005911200. View

Asahina K, Sato H, Yamasaki C, Kataoka M, Shiokawa M, Katayama S . Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Am J Pathol. 2002; 160(6):2191-205. PMC: 1850835. DOI: 10.1016/S0002-9440(10)61167-4. View

Choudhuri R, Zhang H, Donnini S, Ziche M, Bicknell R . An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. Cancer Res. 1997; 57(9):1814-9. View

Shintani T, Watanabe E, Maeda N, Noda M . Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene. Neurosci Lett. 1998; 247(2-3):135-8. DOI: 10.1016/s0304-3940(98)00295-x. View

Huang Y, Hoque M, Wu F, Trink B, Sidransky D, Ratovitski E . Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes. Cell Cycle. 2008; 7(11):1613-22. DOI: 10.4161/cc.7.11.5952. View

Raulo E, Chernousov M, Carey D, Nolo R, Rauvala H . Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). J Biol Chem. 1994; 269(17):12999-3004. View

Agathocleous M, Harris W . From progenitors to differentiated cells in the vertebrate retina. Annu Rev Cell Dev Biol. 2009; 25:45-69. DOI: 10.1146/annurev.cellbio.042308.113259. View

Li Y, Milner P, Chauhan A, Watson M, Hoffman R, Kodner C . Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science. 1990; 250(4988):1690-4. DOI: 10.1126/science.2270483. View

10.

Matt N, Dupe V, Garnier J, Dennefeld C, Chambon P, Mark M . Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development. 2005; 132(21):4789-800. DOI: 10.1242/dev.02031. View

11.

Golden M, Dasen J . Polycomb repressive complex 1 activities determine the columnar organization of motor neurons. Genes Dev. 2012; 26(19):2236-50. PMC: 3465743. DOI: 10.1101/gad.199133.112. View

12.

Creuzet S, Couly G, Le Douarin N . Patterning the neural crest derivatives during development of the vertebrate head: insights from avian studies. J Anat. 2005; 207(5):447-59. PMC: 1571568. DOI: 10.1111/j.1469-7580.2005.00485.x. View

13.

Beebe D, Coats J . The lens organizes the anterior segment: specification of neural crest cell differentiation in the avian eye. Dev Biol. 2001; 220(2):424-31. DOI: 10.1006/dbio.2000.9638. View

14.

Lwigale P, Cressy P, Bronner-Fraser M . Corneal keratocytes retain neural crest progenitor cell properties. Dev Biol. 2005; 288(1):284-93. DOI: 10.1016/j.ydbio.2005.09.046. View

15.

Ohta S, Muramatsu H, Senda T, Zou K, Iwata H, Muramatsu T . Midkine is expressed during repair of bone fracture and promotes chondrogenesis. J Bone Miner Res. 1999; 14(7):1132-44. DOI: 10.1359/jbmr.1999.14.7.1132. View

16.

Calinescu A, Vihtelic T, Hyde D, Hitchcock P . Cellular expression of midkine-a and midkine-b during retinal development and photoreceptor regeneration in zebrafish. J Comp Neurol. 2009; 514(1):1-10. PMC: 3190967. DOI: 10.1002/cne.21999. View

17.

Maeda N, Noda M . Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. J Cell Biol. 1998; 142(1):203-16. PMC: 2133018. DOI: 10.1083/jcb.142.1.203. View

18.

Hay E . Development of the vertebrate cornea. Int Rev Cytol. 1979; 63:263-322. DOI: 10.1016/s0074-7696(08)61760-x. View

19.

Lwigale P, Conrad G, Bronner-Fraser M . Graded potential of neural crest to form cornea, sensory neurons and cartilage along the rostrocaudal axis. Development. 2004; 131(9):1979-91. DOI: 10.1242/dev.01106. View

20.

Lwigale P . Embryonic origin of avian corneal sensory nerves. Dev Biol. 2002; 239(2):323-37. DOI: 10.1006/dbio.2001.0450. View