Changes in the Size of the Thyroid in Patients with Benign Non-toxic Multinodular Goiter After Radioactive Iodine Therapy

Overview

Journal Med J Islam Repub Iran

Specialty General Medicine

Date 2019 Mar 1

PMID 30815426

Citations 1

Authors

Iraj Heydari

Maryam Honardoost

Sedighe Moradi

Fatemeh Golgiri

Hamidreza Dehnad

Saba Moradi

Amir Ziaee

Affiliations

Soon will be listed here.

Abstract

Multinodular goiter (MNG) is regarded as one of the most common causes of hyperthyroidism, particularly in areas of mild-to-moderate iodine deficiency. The present study aims to explore the effects of the radioactive iodine (RAI) therapy on benign non-toxic MNG and evaluate its side effects. Patients with benign non-toxic MNG entered the study. Ultrasonography was applied to calculate the percentage of the decrease in the size of the thyroid before and six months minimum after the treatment. Chi-square, Mann-Whiteny-U and T-test were done using SPSS v.18.0 (p<0.05). The volumes of the thyroid lobes and nodules decreased significantly due to RAI therapy (p<0.001). The total volume of the thyroid, volume of the right nodule, and volume of the left nodule decreased by 77.8%, 40.7%, and 34.6% respectively. According to the results of the current study, RAI therapy is an effective treatment method although it has short-term side effects. This treatment option is recommended for patients with benign non-toxic MNG, notably those who cannot be a candidate for surgery. This treatment affects the size of the thyroid and its nodules significantly and decreases almost all of the complications.

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