Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyl Dichloroethene (DDE) in Human Milk: Effects of Maternal Factors and Previous Lactation

Overview

Journal Am J Public Health

Specialty Public Health

Date 1986 Feb 1

PMID 3080910

Citations 72

Authors

W J Rogan

B C Gladen

J D McKinney

N Carreras

P Hardy

J Thullen

J Tingelstad

M Tully

Affiliations

Soon will be listed here.

Abstract

The authors measured polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in maternal serum, cord blood, placenta, and serial samples of breast milk from 868 women. Almost all samples of breast milk showed detectable levels of both chemicals. Overall, values for DDE in this study are within the range of those found previously, whereas those for PCBs are somewhat higher. Possible causes of variation in levels were investigated. For DDE, older women, Black women, cigarette smokers, and women who consumed sport fish during pregnancy had higher levels; only age and race showed large effects. For PCBs, older women, women who regularly drink alcohol, and primiparae had higher levels. In addition, both chemicals showed modest variation across occupational groupings. Casual exposure to a PCB spill did not result in chemical levels different from background. In general, women have higher levels in their first lactation and in the earlier samples of a given lactation, and levels decline both with time spent breast-feeding and with number of children nursed. These striking declines are presumably a measure of exposure to the child.

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References

Fein G, Jacobson J, Jacobson S, Schwartz P, Dowler J . Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr. 1984; 105(2):315-20. DOI: 10.1016/s0022-3476(84)80139-0. View

Mes J, Doyle J, Adams B, Davies D, Turton D . Polychlorinated biphenyls and organochlorine pesticides in milk and blood of Canadian women during lactation. Arch Environ Contam Toxicol. 1984; 13(2):217-23. DOI: 10.1007/BF01055879. View

Laws Jr E, Curley A, Biros F . Men with intensive occupational exposure to DDT. A clinical and chemical study. Arch Environ Health. 1967; 15(6):766-75. DOI: 10.1080/00039896.1967.10664995. View

HAYES Jr W, DALE W, PIRKLE C . Evidence of safety of long-term, high, oral doses of DDT for man. Arch Environ Health. 1971; 22(1):119-35. DOI: 10.1080/00039896.1971.10665822. View

Finklea J, Priester L, Creason J, Hauser T, Hinners T, Hammer D . Polychlorinated biphenyl residues in human plasma expose a major urban pollution problem. Am J Public Health. 1972; 62(5):645-51. PMC: 1530247. DOI: 10.2105/ajph.62.5.645. View

Davies J, EDMUNDSON W, Raffonelli A, Cassady J, Morgade C . The role of social class in human pesticide pollution. Am J Epidemiol. 1972; 96(5):334-41. DOI: 10.1093/oxfordjournals.aje.a121464. View

Masuda Y, Kagawa R, Kurantsune M . Comparison of polychlorinated biphenyls in yusho patients and ordinary persons. Bull Environ Contam Toxicol. 1974; 11(3):213-6. DOI: 10.1007/BF01685094. View

Barsotti D, Marlar R, Allen J . Reproductive dysfunction in rhesus monkeys exposed to low levels of polychlorinated biphenyls (Aoroclor 1248). Food Cosmet Toxicol. 1976; 14(2):99-103. DOI: 10.1016/s0015-6264(76)80251-9. View

Allen J, Barsotti D . The effects of transplacental and mammary movement of PCBs on infant rhesus monkeys. Toxicology. 1976; 6(3):331-40. DOI: 10.1016/0300-483x(76)90037-8. View

10.

POLISHUK Z, Wassermann D, Wassermann M, Cucos S, Ron M . Organochlorine compounds in mother and fetus during labor. Environ Res. 1977; 13(2):278-84. DOI: 10.1016/0013-9351(77)90104-9. View

11.

Kutz F, Yobs A, Strassman S . Racial stratification of organochlorine insecticide residues in human adipose tissue. J Occup Med. 1977; 19(9):619-22. View

12.

Kuwabara K, Yakushiji T, Watanabe I, Yoshida S, Koyama K, KUNITA N . Relationship between breast feeding and PCB residues in blood of the children whose mothers were occupationally exposed to PCBs. Int Arch Occup Environ Health. 1978; 41(3):189-97. DOI: 10.1007/BF00572891. View

13.

Bowman R, Heironimus M, Allen J . Correlation of PCB body burden with behavioral toxicology in monkeys. Pharmacol Biochem Behav. 1978; 9(1):49-56. DOI: 10.1016/0091-3057(78)90012-6. View

14.

Masuda Y, Kagawa R, Kuroki H, Kuratsune M, Yoshimura T, Taki I . Transfer of polychlorinated biphenyls from mothers to foetuses and infants. Food Cosmet Toxicol. 1978; 16(6):543-6. DOI: 10.1016/s0015-6264(78)80221-1. View

15.

Kodama H, Ota H . Transfer of polychlorinated biphenyls to infants from their mothers. Arch Environ Health. 1980; 35(2):95-100. View

16.

Parkinson A, Robertson L, Safe S . Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase. Biochem Biophys Res Commun. 1980; 96(2):882-9. DOI: 10.1016/0006-291x(80)91438-2. View

17.

Shimada T, Sato R . Covalent binding of polychlorinated biphenyls to rat liver microsomes in vitro: nature of reactive metabolites and target macromolecules. Toxicol Appl Pharmacol. 1980; 55(3):490-500. DOI: 10.1016/0041-008x(80)90051-4. View

18.

Wickizer T, Brilliant L, Copeland R, Tilden R . Polychlorinated biphenyl contamination of nursing mothers' milk in Michigan. Am J Public Health. 1981; 71(2):132-7. PMC: 1619635. DOI: 10.2105/ajph.71.2.132. View

19.

Savage E, Keefe T, Tessari J, WHEELER H, Applehans F, Goes E . National study of chlorinated hydrocarbon insecticide residues in human milk, USA. I. Geographic distribution of dieldrin, heptachlor, heptachlor epoxide, chlordane, oxychlordane, and mirex. Am J Epidemiol. 1981; 113(4):413-22. DOI: 10.1093/oxfordjournals.aje.a113109. View

20.

Kreiss K, Zack M, Kimbrough R, Needham L, Smrek A, Jones B . Cross-sectional study of a community with exceptional exposure to DDT. JAMA. 1981; 245(19):1926-30. View