Acquired Von Willebrand Syndrome in Patients With Ventricular Assist Device

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2019 Feb 27

PMID 30805339

Citations 11

Authors

Antoine Rauch

Sophie Susen

Barbara Zieger

Affiliations

Soon will be listed here.

Abstract

During the last decade the use of ventricular assist devices (VADs) for patients with severe heart failure has increased tremendously. However, flow disturbances, mainly high shear induced by the device is associated with bleeding complications. Shear stress-induced changes in VWF conformation are associated with a loss of high molecular weight multimers (HMW) of VWF and an increased risk of bleeding. This phenomenon and its cause will be elaborated and reviewed in the following.

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