Benefits and Inputs From Lactic Acid Bacteria and Their Bacteriocins As Alternatives to Antibiotic Growth Promoters During Food-Animal Production

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2019 Feb 27

PMID 30804896

Citations 178

Authors

Nuria Vieco-Saiz

Yanath Belguesmia

Ruth Raspoet

Eric Auclair

Frederique Gancel

Isabelle Kempf

Djamel Drider

Affiliations

Soon will be listed here.

Abstract

Resistance to antibiotics is escalating and threatening humans and animals worldwide. Different countries have legislated or promoted the ban of antibiotics as growth promoters in livestock and aquaculture to reduce this phenomenon. Therefore, to improve animal growth and reproduction performance and to control multiple bacterial infections, there is a potential to use probiotics as non-antibiotic growth promoters. Lactic acid bacteria (LAB) offer various advantages as potential probiotics and can be considered as alternatives to antibiotics during food-animal production. LAB are safe microorganisms with abilities to produce different inhibitory compounds such as bacteriocins, organic acids as lactic acid, hydrogen peroxide, diacetyl, and carbon dioxide. LAB can inhibit harmful microorganisms with their arsenal, or through competitive exclusion mechanism based on competition for binding sites and nutrients. LAB endowed with specific enzymatic functions (amylase, protease…) can improve nutrients acquisition as well as animal immune system stimulation. This review aimed at underlining the benefits and inputs from LAB as potential alternatives to antibiotics in poultry, pigs, ruminants, and aquaculture production.

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References

Ruas-Madiedo P, Medrano M, Salazar N, G de Los Reyes-Gavilan C, Perez P, Abraham A . Exopolysaccharides produced by Lactobacillus and Bifidobacterium strains abrogate in vitro the cytotoxic effect of bacterial toxins on eukaryotic cells. J Appl Microbiol. 2010; 109(6):2079-86. DOI: 10.1111/j.1365-2672.2010.04839.x. View

Pizzolitto R, Salvano M, Dalcero A . Analysis of fumonisin B1 removal by microorganisms in co-occurrence with aflatoxin B1 and the nature of the binding process. Int J Food Microbiol. 2012; 156(3):214-21. DOI: 10.1016/j.ijfoodmicro.2012.03.024. View

Soucy S, Huang J, Gogarten J . Horizontal gene transfer: building the web of life. Nat Rev Genet. 2015; 16(8):472-82. DOI: 10.1038/nrg3962. View

Yang W, Yang G, Shi S, Liu Y, Huang H, Jiang Y . Protection of chickens against H9N2 avian influenza virus challenge with recombinant Lactobacillus plantarum expressing conserved antigens. Appl Microbiol Biotechnol. 2017; 101(11):4593-4603. DOI: 10.1007/s00253-017-8230-8. View

Niewold T . The nonantibiotic anti-inflammatory effect of antimicrobial growth promoters, the real mode of action? A hypothesis. Poult Sci. 2007; 86(4):605-9. DOI: 10.1093/ps/86.4.605. View

Allen A, Flemstrom G . Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol. 2004; 288(1):C1-19. DOI: 10.1152/ajpcell.00102.2004. View

Luongo D, Miyamoto J, Bergamo P, Nazzaro F, Baruzzi F, Sashihara T . Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri. BMC Microbiol. 2013; 13:298. PMC: 3879436. DOI: 10.1186/1471-2180-13-298. View

Yang F, Hou C, Zeng X, Qiao S . The use of lactic Acid bacteria as a probiotic in Swine diets. Pathogens. 2015; 4(1):34-45. PMC: 4384071. DOI: 10.3390/pathogens4010034. View

Araujo C, Munoz-Atienza E, Poeta P, Igrejas G, Hernandez P, Herranz C . Characterization of Pediococcus acidilactici strains isolated from rainbow trout (Oncorhynchus mykiss) feed and larvae: safety, DNA fingerprinting, and bacteriocinogenicity. Dis Aquat Organ. 2016; 119(2):129-43. DOI: 10.3354/dao02992. View

10.

Park Y, Hamidon F, Rajangan C, Soh K, Gan C, Lim T . Application of Probiotics for the Production of Safe and High-quality Poultry Meat. Korean J Food Sci Anim Resour. 2016; 36(5):567-576. PMC: 5112418. DOI: 10.5851/kosfa.2016.36.5.567. View

11.

Gao X, Zhang M, Li X, Han Y, Wu F, Liu Y . The effects of feeding Lactobacillus pentosus on growth, immunity, and disease resistance in Haliotis discus hannai Ino. Fish Shellfish Immunol. 2018; 78:42-51. DOI: 10.1016/j.fsi.2018.04.010. View

12.

Chaucheyras-Durand F, Durand H . Probiotics in animal nutrition and health. Benef Microbes. 2011; 1(1):3-9. DOI: 10.3920/BM2008.1002. View

13.

Santini C, Baffoni L, Gaggia F, Granata M, Gasbarri R, Di Gioia D . Characterization of probiotic strains: an application as feed additives in poultry against Campylobacter jejuni. Int J Food Microbiol. 2010; 141 Suppl 1:S98-108. DOI: 10.1016/j.ijfoodmicro.2010.03.039. View

14.

Naghmouchi K, Belguesmia Y, Baah J, Teather R, Drider D . Antibacterial activity of class I and IIa bacteriocins combined with polymyxin E against resistant variants of Listeria monocytogenes and Escherichia coli. Res Microbiol. 2010; 162(2):99-107. DOI: 10.1016/j.resmic.2010.09.014. View

15.

Arruda P, Madson D, Ramirez A, Rowe E, Songer J . Bacterial probiotics as an aid in the control of Clostridium difficile disease in neonatal pigs. Can Vet J. 2016; 57(2):183-8. PMC: 4712999. View

16.

Caly D, Chevalier M, Flahaut C, Cudennec B, Al Atya A, Chataigne G . The safe enterocin DD14 is a leaderless two-peptide bacteriocin with anti-Clostridium perfringens activity. Int J Antimicrob Agents. 2017; 49(3):282-289. DOI: 10.1016/j.ijantimicag.2016.11.016. View

17.

Drider D, Bendali F, Naghmouchi K, Chikindas M . Bacteriocins: Not Only Antibacterial Agents. Probiotics Antimicrob Proteins. 2016; 8(4):177-182. DOI: 10.1007/s12602-016-9223-0. View

18.

Aguilar-Perez C, Gracia B, Rodrigues L, Vitoria A, Cebrian R, Deboosere N . Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2018; 62(9). PMC: 6125546. DOI: 10.1128/AAC.00359-18. View

19.

Saleem A, Zanouny A, Singer A . Growth performance, nutrients digestibility, and blood metabolites of lambs fed diets supplemented with probiotics during pre- and post-weaning period. Asian-Australas J Anim Sci. 2016; 30(4):523-530. PMC: 5394838. DOI: 10.5713/ajas.16.0691. View

20.

Liao S, Nyachoti M . Using probiotics to improve swine gut health and nutrient utilization. Anim Nutr. 2018; 3(4):331-343. PMC: 5941265. DOI: 10.1016/j.aninu.2017.06.007. View