Exogenous Neural Stem Cell Transplantation for Cerebral Ischemia

Overview

Journal Neural Regen Res

Date 2019 Feb 27

PMID 30804235

Citations 26

Authors

Ling-Yi Liao

Benson Wui-Man Lau

Dalinda Isabel Sanchez-Vidana

Qiang Gao

Affiliations

Soon will be listed here.

Abstract

Cerebral ischemic injury is the main manifestation of stroke, and its incidence in stroke patients is 70-80%. Although ischemic stroke can be treated with tissue-type plasminogen activator, its time window of effectiveness is narrow. Therefore, the incidence of paralysis, hypoesthesia, aphasia, dysphagia, and cognitive impairment caused by cerebral ischemia is high. Nerve tissue regeneration can promote the recovery of the aforementioned dysfunction. Neural stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain tissue. Neural stem cell transplantation for ischemic stroke has been a hot topic for more than 10 years. This review discusses the treatment of ischemic stroke with neural stem cells, as well as the mechanisms of their involvement in stroke treatment.

Citing Articles

Human iPSC-derived neural stem cells displaying radial glia signature exhibit long-term safety in mice.

Luciani M, Garsia C, Beretta S, Cifola I, Peano C, Merelli I Nat Commun. 2024; 15(1):9433.

PMID: 39487141 PMC: 11530573. DOI: 10.1038/s41467-024-53613-7.

Recent research of peptide-based hydrogel in nervous regeneration.

Xie C, Chen Y, Wang L, Liao K, Xue B, Han Y Bioact Mater. 2024; 40:503-523.

PMID: 39040568 PMC: 11261279. DOI: 10.1016/j.bioactmat.2024.06.013.

Na+/K+-ATPase: ion pump, signal transducer, or cytoprotective protein, and novel biological functions.

Huang S, Dong W, Lin X, Bian J Neural Regen Res. 2024; 19(12):2684-2697.

PMID: 38595287 PMC: 11168508. DOI: 10.4103/NRR.NRR-D-23-01175.

Recent advances in tissue repair of the blood-brain barrier after stroke.

Qi L, Wang F, Sun X, Li H, Zhang K, Li J J Tissue Eng. 2024; 15:20417314241226551.

PMID: 38304736 PMC: 10832427. DOI: 10.1177/20417314241226551.

Polymeric-Micelle-Based Delivery Systems for Nucleic Acids.

Sinani G, Durgun M, Cevher E, Ozsoy Y Pharmaceutics. 2023; 15(8).

PMID: 37631235 PMC: 10457940. DOI: 10.3390/pharmaceutics15082021.

References

Doetsch F, Caille I, Lim D, Garcia-Verdugo J, Alvarez-Buylla A . Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 1999; 97(6):703-16. DOI: 10.1016/s0092-8674(00)80783-7. View

Clarke D, Johansson C, Wilbertz J, Veress B, Nilsson E, Karlstrom H . Generalized potential of adult neural stem cells. Science. 2000; 288(5471):1660-3. DOI: 10.1126/science.288.5471.1660. View

Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn K, Gebel J . Transplantation of cultured human neuronal cells for patients with stroke. Neurology. 2000; 55(4):565-9. DOI: 10.1212/wnl.55.4.565. View

Carleton A, Petreanu L, Lansford R, Alvarez-Buylla A, Lledo P . Becoming a new neuron in the adult olfactory bulb. Nat Neurosci. 2003; 6(5):507-18. DOI: 10.1038/nn1048. View

Barbash I, Chouraqui P, Baron J, Feinberg M, Etzion S, Tessone A . Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation. 2003; 108(7):863-8. DOI: 10.1161/01.CIR.0000084828.50310.6A. View

Altman J . Are new neurons formed in the brains of adult mammals?. Science. 1962; 135(3509):1127-8. DOI: 10.1126/science.135.3509.1127. View

Sanai N, Tramontin A, Quinones-Hinojosa A, Barbaro N, Gupta N, Kunwar S . Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature. 2004; 427(6976):740-4. DOI: 10.1038/nature02301. View

Ishibashi S, Sakaguchi M, Kuroiwa T, Yamasaki M, Kanemura Y, Shizuko I . Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils. J Neurosci Res. 2004; 78(2):215-23. DOI: 10.1002/jnr.20246. View

Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I . Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique. J Neurosurg Spine. 2004; 1(3):330-7. DOI: 10.3171/spi.2004.1.3.0330. View

10.

Garcia A, Doan N, Imura T, Bush T, Sofroniew M . GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci. 2004; 7(11):1233-41. DOI: 10.1038/nn1340. View

11.

Lepore A, Bakshi A, Swanger S, Rao M, Fischer I . Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Res. 2005; 1045(1-2):206-16. DOI: 10.1016/j.brainres.2005.03.050. View

12.

Savitz S, Dinsmore J, Wu J, Henderson G, Stieg P, Caplan L . Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis. 2005; 20(2):101-7. DOI: 10.1159/000086518. View

13.

Kondziolka D, Steinberg G, Wechsler L, Meltzer C, Elder E, Gebel J . Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg. 2005; 103(1):38-45. DOI: 10.3171/jns.2005.103.1.0038. View

14.

Rabinovich S, Seledtsov V, Banul N, Poveshchenko O, Senyukov V, Astrakov S . Cell therapy of brain stroke. Bull Exp Biol Med. 2005; 139(1):126-8. DOI: 10.1007/s10517-005-0229-y. View

15.

Wieloch T, Nikolich K . Mechanisms of neural plasticity following brain injury. Curr Opin Neurobiol. 2006; 16(3):258-64. DOI: 10.1016/j.conb.2006.05.011. View

16.

Bacigaluppi M, Pluchino S, Martino G, Kilic E, Hermann D . Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci. 2007; 265(1-2):73-7. DOI: 10.1016/j.jns.2007.06.012. View

17.

Kameda M, Shingo T, Takahashi K, Muraoka K, Kurozumi K, Yasuhara T . Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemia. Eur J Neurosci. 2007; 26(6):1462-78. DOI: 10.1111/j.1460-9568.2007.05776.x. View

18.

Morizane A, Li J, Brundin P . From bench to bed: the potential of stem cells for the treatment of Parkinson's disease. Cell Tissue Res. 2007; 331(1):323-36. DOI: 10.1007/s00441-007-0541-0. View

19.

Zhao C, Deng W, Gage F . Mechanisms and functional implications of adult neurogenesis. Cell. 2008; 132(4):645-60. DOI: 10.1016/j.cell.2008.01.033. View

20.

Walczak P, Zhang J, Gilad A, Kedziorek D, Ruiz-Cabello J, Young R . Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke. 2008; 39(5):1569-74. PMC: 2857730. DOI: 10.1161/STROKEAHA.107.502047. View