Altered Resistin Concentrations in Mid-trimester Amniotic Fluid of Fetuses With Trisomies 18 and 13: A Window Onto the Pathophysiology of Trisomies 18 and 13

Overview

Journal In Vivo

Specialty Oncology

Date 2019 Feb 27

PMID 30804122

Citations 1

Authors

Nikolaos Vrachnis

Erminia Dalakli

Dimitrios Zygouris

Nikolaos Vlachadis

Nikolaos Salakos

Dimitrios Botsis

Sophia Kalantaridou

Nikolaos Drakoulis

George Mastorakos

George Creatsas

Efthymios Deligeoroglou

Zoe Iliodromiti

Affiliations

Soon will be listed here.

Abstract

Background/aim: The study aimed to examine whether resistin is present in second trimester amniotic fluid from pregnancies with trisomy 18 and 13 and evaluate its concentration in comparison with euploid pregnancies.

Patients And Methods: The study included 37 women who underwent amniocentesis. Eleven fetuses had trisomy 18, 3 had trisomy 13, while 23 had a normal karyotype.

Results: Resistin was detected in all cases. The mean level of resistin in trisomy 18 was statistically significantly lower compared to euploid controls. Resistin levels in all abnormal cases were below its median concentration in euploid controls. ROC analysis showed very good prognostic value for both trisomies.

Conclusion: Resistin is a constituent of mid-trimester amniotic fluid of pregnancies with trisomies 13 and 18, exhibiting lower levels than those in euploid fetuses. The reduced levels of resistin in amniotic fluid may be associated with early changes in metabolic pathways and immunoinflammatory responses.

Citing Articles

Future Perspectives in Oxidative Stress in Trisomy 13 and 18 Evaluation.

Buczynska A, Sidorkiewicz I, Hameed A, Kretowski A, Zbucka-Kretowska M J Clin Med. 2022; 11(7).

PMID: 35407395 PMC: 8999694. DOI: 10.3390/jcm11071787.

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