How to Eliminate Taeniasis/cysticercosis: Porcine Vaccination and Human Chemotherapy (Part 2)

Overview

Journal Theor Biol Med Model

Publisher Biomed Central

Date 2019 Feb 27

PMID 30803437

Citations 11

Authors

Norma Y Sanchez-Torres

Juan R Bobadilla

Juan P Laclette

Marco V Jose

Affiliations

Soon will be listed here.

Abstract

Background: The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the feasibility of interrupting the parasite's life cycle in endemic areas.

Methods: A mathematical model that divides the population into susceptible, infected, and vaccinated individuals is formulated. The model is based upon the life cycle of the parasite. Computer numerical simulation experiments to evaluate the impact of pig vaccination under different vaccination schedules, and combined intervention strategies including pig vaccination and anthelmintic treatment against human taeniasis are carried out.

Results: Vaccination against either pig cysticercosis or against human taeniasis will influence the transmission dynamics not only among vaccinees but also the dynamics of the other hosts as well. When the protective efficacy and/or the coverage rate is less than 100%, different mass interventions like vaccinating the pig population twice in combination with chemotherapeutic treatment against human taeniasis, the elimination of the infection in both pigs and humans can also be achieved.

Conclusions: Our mathematical model has the potential for planning, and designing effective intervention strategies including both mass vaccination and/or chemotherapeutic treatment to eliminate pig cysticercosis, human taeniasis and human neurocysticercosis. The model can be adapted to any given community with mild, moderate endemicity, or even in hyperendemic regions.

Citing Articles

CystiHuman: A model of human neurocysticercosis.

Bonnet G, Pizzitutti F, Gonzales-Gustavson E, Gabriel S, Pan W, Garcia H PLoS Comput Biol. 2022; 18(5):e1010118.

PMID: 35587497 PMC: 9159625. DOI: 10.1371/journal.pcbi.1010118.

Optimal control analysis of bovine cysticercosis and human taeniasis.

Mwasunda J, Irunde J, Kajunguri D, Kuznetsov D Parasite Epidemiol Control. 2022; 16:e00236.

PMID: 35028439 PMC: 8741606. DOI: 10.1016/j.parepi.2021.e00236.

Validation of a spatial agent-based model for Taenia solium transmission ("CystiAgent") against a large prospective trial of control strategies in northern Peru.

Pray I, Pizzitutti F, Bonnet G, Gonzales-Gustavson E, Wakeland W, Pan W PLoS Negl Trop Dis. 2021; 15(10):e0009885.

PMID: 34705827 PMC: 8575314. DOI: 10.1371/journal.pntd.0009885.

Neurocysticercosis: Current Perspectives on Diagnosis and Management.

Butala C, Brook T, Majekodunmi A, Welburn S Front Vet Sci. 2021; 8:615703.

PMID: 34041288 PMC: 8141574. DOI: 10.3389/fvets.2021.615703.

Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar.

Ramiandrasoa N, Ravoniarimbinina P, Solofoniaina A, Andrianjafy Rakotomanga I, Andrianarisoa S, Molia S PLoS Negl Trop Dis. 2020; 14(9):e0008653.

PMID: 32946447 PMC: 7500903. DOI: 10.1371/journal.pntd.0008653.

References

Eckert J, Deplazes P . Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clin Microbiol Rev. 2004; 17(1):107-35. PMC: 321468. DOI: 10.1128/CMR.17.1.107-135.2004. View

Flisser A, Gauci C, Zoli A, Martinez-Ocana J, Garza-Rodriguez A, Dominguez-Alpizar J . Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infect Immun. 2004; 72(9):5292-7. PMC: 517464. DOI: 10.1128/IAI.72.9.5292-5297.2004. View

Gonzalez A, Gauci C, Barber D, Gilman R, Tsang V, Garcia H . Vaccination of pigs to control human neurocysticercosis. Am J Trop Med Hyg. 2005; 72(6):837-9. View

Kyvsgaard N, Johansen M, Carabin H . Simulating transmission and control of Taenia solium infections using a Reed-Frost stochastic model. Int J Parasitol. 2007; 37(5):547-58. DOI: 10.1016/j.ijpara.2006.11.018. View

Lightowlers M . Cestode vaccines: origins, current status and future prospects. Parasitology. 2007; 133 Suppl:S27-42. DOI: 10.1017/S003118200600179X. View

Garcia H, Moro P, Schantz P . Zoonotic helminth infections of humans: echinococcosis, cysticercosis and fascioliasis. Curr Opin Infect Dis. 2007; 20(5):489-94. DOI: 10.1097/QCO.0b013e3282a95e39. View

Budke C, White Jr A, Garcia H . Zoonotic larval cestode infections: neglected, neglected tropical diseases?. PLoS Negl Trop Dis. 2009; 3(2):e319. PMC: 2638007. DOI: 10.1371/journal.pntd.0000319. View

Brunetti E, Kern P, Vuitton D . Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2009; 114(1):1-16. DOI: 10.1016/j.actatropica.2009.11.001. View

Assana E, Kyngdon C, Gauci C, Geerts S, Dorny P, De Deken R . Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon. Int J Parasitol. 2010; 40(5):515-9. PMC: 2856920. DOI: 10.1016/j.ijpara.2010.01.006. View

10.

Lightowlers M . Eradication of Taenia solium cysticercosis: a role for vaccination of pigs. Int J Parasitol. 2010; 40(10):1183-92. DOI: 10.1016/j.ijpara.2010.05.001. View

11.

Ndimubanzi P, Carabin H, Budke C, Nguyen H, Qian Y, Rainwater E . A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy. PLoS Negl Trop Dis. 2010; 4(11):e870. PMC: 2970544. DOI: 10.1371/journal.pntd.0000870. View

12.

Torgerson P, Macpherson C . The socioeconomic burden of parasitic zoonoses: global trends. Vet Parasitol. 2011; 182(1):79-95. DOI: 10.1016/j.vetpar.2011.07.017. View

13.

Coyle C, Mahanty S, Zunt J, Wallin M, Cantey P, White Jr A . Neurocysticercosis: neglected but not forgotten. PLoS Negl Trop Dis. 2012; 6(5):e1500. PMC: 3362619. DOI: 10.1371/journal.pntd.0001500. View

14.

Del Brutto O, Garcia H . Neurocysticercosis in nonendemic countries: time for a reappraisal. Neuroepidemiology. 2012; 39(2):145-6. DOI: 10.1159/000341693. View

15.

Tsai I, Zarowiecki M, Holroyd N, Garciarrubio A, Sanchez-Flores A, Brooks K . The genomes of four tapeworm species reveal adaptations to parasitism. Nature. 2013; 496(7443):57-63. PMC: 3964345. DOI: 10.1038/nature12031. View

16.

Nash T, Mahanty S, Garcia H . Neurocysticercosis-more than a neglected disease. PLoS Negl Trop Dis. 2013; 7(4):e1964. PMC: 3636045. DOI: 10.1371/journal.pntd.0001964. View

17.

Keilbach N, de Aluja A . A programme to control taeniasis-cysticercosis (T. solium): experiences in a Mexican village. Acta Leiden. 1989; 57(2):181-9. View

18.

Gabriel S, Johansen M, Pozio E, Smit G, Devleesschauwer B, Allepuz A . Human migration and pig/pork import in the European Union: What are the implications for Taenia solium infections?. Vet Parasitol. 2015; 213(1-2):38-45. DOI: 10.1016/j.vetpar.2015.03.006. View

19.

Lightowlers M, Donadeu M, Elaiyaraja M, Maithal K, Kumar K, Gauci C . Anamnestic responses in pigs to the Taenia solium TSOL18 vaccine and implications for control strategies. Parasitology. 2016; 143(4):416-20. DOI: 10.1017/S0031182016000202. View

20.

Okello A, Thomas L, Inthavong P, Ash A, Khamlome B, Keokamphet C . Assessing the impact of a joint human-porcine intervention package for Taenia solium control: Results of a pilot study from northern Lao PDR. Acta Trop. 2016; 159:185-91. DOI: 10.1016/j.actatropica.2016.03.012. View