Retinoic Acid Signaling in Vascular Development

Overview

Journal Genesis

Specialties Biology
Molecular Biology

Date 2019 Feb 26

PMID 30801891

Citations 21

Authors

Brad Pawlikowski

Jacob Wragge

Julie A Siegenthaler

Affiliations

Soon will be listed here.

Abstract

Formation of the vasculature is an essential developmental process, delivering oxygen and nutrients to support cellular processes needed for tissue growth and maturation. Retinoic acid (RA) and its downstream signaling pathway is vital for normal pre- and post-natal development, playing key roles in the specification and formation of many organs and tissues. Here, we review the role of RA in blood and lymph vascular development, beginning with embryonic yolk sac vasculogenesis and remodeling and discussing RA's organ-specific roles in angiogenesis and vessel maturation. In particular, we highlight the multi-faceted role of RA signaling in CNS vascular development and acquisition of blood-brain barrier properties.

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