Nanoparticle Technology and Stem Cell Therapy Team Up Against Neurodegenerative Disorders

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2019 Feb 25

PMID 30797953

Citations 46

Authors

Caroline Vissers

Guo-Li Ming

Hongjun Song

Affiliations

Soon will be listed here.

Abstract

The convergence of nanoparticles and stem cell therapy holds great promise for the study, diagnosis, and treatment of neurodegenerative disorders. Researchers aim to harness the power of nanoparticles to regulate cellular microenvironment, improve the efficiency of cell and drug delivery to the brain, and enhance the survival of stem cell transplants. Understanding the various properties of different nanoparticles is key to applying them to clinical therapies; the many distinct types of nanoparticles offer unique capacities for medical imaging, diagnosis, and treatment of neurodegeneration disorders. In this review we introduce the biology of Alzheimer's, Parkinson's Disease, and amyotrophic lateral sclerosis, and discuss the potentials and shortcomings of metal, silica, lipid-based, polymeric, and hydrogel nanoparticles for diagnosis and treatment of neurodegenerative disorders. We then provide an overview of current strategies in stem cell therapies and how they can be combined with nanotechnology to improve clinical outcomes.

Citing Articles

Applications of Gene Editing and Nanotechnology in Stem Cell-Based Therapies for Human Diseases.

Bolideei M, Barzigar R, Gahrouei R, Mohebbi E, Haider K, Paul S Stem Cell Rev Rep. 2025; .

PMID: 40014250 DOI: 10.1007/s12015-025-10857-0.

Advances in hydrogel for diagnosis and treatment for Parkinson's disease.

Zhu P, Zhao Z, Gao Y Front Pharmacol. 2025; 16:1552586.

PMID: 40012627 PMC: 11860083. DOI: 10.3389/fphar.2025.1552586.

Advances in Stem Cell Therapy for Huntington's Disease: A Comprehensive Literature Review.

Shah S, Mansour H, Lucke-Wold B Cells. 2025; 14(1.

PMID: 39791743 PMC: 11719515. DOI: 10.3390/cells14010042.

Stem cell transplantation therapy for advanced liver damage-associated neurodegenerative disorders.

Sharma A, Sharma A, Dheer D, Sharma R, Puri V, Bibi S Int J Surg. 2024; 110(11):6873-6882.

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Overcoming challenges in the design of drug delivery systems targeting the central nervous system.

Almutary A, Chauhan P, Baldaniya L, Menon S, Kumar M, Chaturvedi B Nanomedicine (Lond). 2024; 20(1):5-8.

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