Global Connectivity of the Fronto-parietal Cognitive Control Network is Related to Depression Symptoms in the General Population

Overview

Journal Netw Neurosci

Publisher MIT Press

Specialty Neurology

Date 2019 Feb 23

PMID 30793076

Citations 32

Authors

Douglas H Schultz

Takuya Ito

Levi I Solomyak

Richard H Chen

Ravi D Mill

Alan Anticevic

Michael W Cole

Affiliations

Soon will be listed here.

Abstract

We all vary in our mental health, even among people not meeting diagnostic criteria for mental illness. Understanding this individual variability may reveal factors driving the risk for mental illness, as well as factors driving subclinical problems that still adversely affect quality of life. To better understand the large-scale brain network mechanisms underlying this variability, we examined the relationship between mental health symptoms and resting-state functional connectivity patterns in cognitive control systems. One such system is the fronto-parietal cognitive control network (FPN). Changes in FPN connectivity may impact mental health by disrupting the ability to regulate symptoms in a goal-directed manner. Here we test the hypothesis that FPN dysconnectivity relates to mental health symptoms even among individuals who do not meet formal diagnostic criteria but may exhibit meaningful symptom variation. We found that depression symptoms severity negatively correlated with between-network global connectivity (BGC) of the FPN. This suggests that decreased connectivity between the FPN and the rest of the brain is related to increased depression symptoms in the general population. These findings complement previous clinical studies to support the hypothesis that global FPN connectivity contributes to the regulation of mental health symptoms across both health and disease.

Citing Articles

Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis.

Saberi A, Ebneabbasi A, Rahimi S, Sarebannejad S, Sen Z, Graf H Mol Psychiatry. 2024; 30(2):736-751.

PMID: 39406999 PMC: 11746144. DOI: 10.1038/s41380-024-02780-6.

Insomnia and stress: the mediating roles of frontoparietal network.

He M, Li Y, Chen M, Li H, Liang C, Chen Y Brain Imaging Behav. 2024; 18(6):1355-1365.

PMID: 39269599 DOI: 10.1007/s11682-024-00922-6.

Differences in Children and Adolescents with Depression before and after a Remediation Program: An Event-Related Potential Study.

Zygouris N Brain Sci. 2024; 14(7).

PMID: 39061401 PMC: 11275103. DOI: 10.3390/brainsci14070660.

Annual Research Review: Neuroimmune network model of depression: a developmental perspective.

Nusslock R, Alloy L, Brody G, Miller G J Child Psychol Psychiatry. 2024; 65(4):538-567.

PMID: 38426610 PMC: 11090270. DOI: 10.1111/jcpp.13961.

Mild Behavioral Impairment in Parkinson's Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects.

Angelopoulou E, Bougea A, Hatzimanolis A, Stefanis L, Scarmeas N, Papageorgiou S Medicina (Kaunas). 2024; 60(1).

PMID: 38256375 PMC: 10820007. DOI: 10.3390/medicina60010115.

References

Cole J, Rabin A, Smith T, Kaufman A . Development and validation of a Rasch-derived CES-D short form. Psychol Assess. 2004; 16(4):360-72. DOI: 10.1037/1040-3590.16.4.360. View

Chein J, Schneider W . Neuroimaging studies of practice-related change: fMRI and meta-analytic evidence of a domain-general control network for learning. Brain Res Cogn Brain Res. 2005; 25(3):607-23. DOI: 10.1016/j.cogbrainres.2005.08.013. View

Greicius M, Flores B, Menon V, Glover G, Solvason H, Kenna H . Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry. 2007; 62(5):429-37. PMC: 2001244. DOI: 10.1016/j.biopsych.2006.09.020. View

Cole M, Schneider W . The cognitive control network: Integrated cortical regions with dissociable functions. Neuroimage. 2007; 37(1):343-60. DOI: 10.1016/j.neuroimage.2007.03.071. View

Dosenbach N, Fair D, Miezin F, Cohen A, Wenger K, Dosenbach R . Distinct brain networks for adaptive and stable task control in humans. Proc Natl Acad Sci U S A. 2007; 104(26):11073-8. PMC: 1904171. DOI: 10.1073/pnas.0704320104. View

Banks S, Eddy K, Angstadt M, Nathan P, Phan K . Amygdala-frontal connectivity during emotion regulation. Soc Cogn Affect Neurosci. 2008; 2(4):303-12. PMC: 2566753. DOI: 10.1093/scan/nsm029. View

Sheline Y, Barch D, Price J, Rundle M, Vaishnavi S, Snyder A . The default mode network and self-referential processes in depression. Proc Natl Acad Sci U S A. 2009; 106(6):1942-7. PMC: 2631078. DOI: 10.1073/pnas.0812686106. View

Buckner R, Sepulcre J, Talukdar T, Krienen F, Liu H, Hedden T . Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 2009; 29(6):1860-73. PMC: 2750039. DOI: 10.1523/JNEUROSCI.5062-08.2009. View

Cole M, Pathak S, Schneider W . Identifying the brain's most globally connected regions. Neuroimage. 2009; 49(4):3132-48. DOI: 10.1016/j.neuroimage.2009.11.001. View

10.

Baune B, Miller R, McAfoose J, Johnson M, Quirk F, Mitchell D . The role of cognitive impairment in general functioning in major depression. Psychiatry Res. 2010; 176(2-3):183-9. DOI: 10.1016/j.psychres.2008.12.001. View

11.

Dumontheil I, Thompson R, Duncan J . Assembly and use of new task rules in fronto-parietal cortex. J Cogn Neurosci. 2010; 23(1):168-82. DOI: 10.1162/jocn.2010.21439. View

12.

Duncan J . The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. Trends Cogn Sci. 2010; 14(4):172-9. DOI: 10.1016/j.tics.2010.01.004. View

13.

Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo B, Buckner R . The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol. 2010; 6(6):e1000808. PMC: 2883589. DOI: 10.1371/journal.pcbi.1000808. View

14.

Van Dam N, Earleywine M . Validation of the Center for Epidemiologic Studies Depression Scale--Revised (CESD-R): pragmatic depression assessment in the general population. Psychiatry Res. 2010; 186(1):128-32. DOI: 10.1016/j.psychres.2010.08.018. View

15.

. Current depression among adults---United States, 2006 and 2008. MMWR Morb Mortal Wkly Rep. 2010; 59(38):1229-35. View

16.

Veer I, Beckmann C, van Tol M, Ferrarini L, Milles J, Veltman D . Whole brain resting-state analysis reveals decreased functional connectivity in major depression. Front Syst Neurosci. 2010; 4. PMC: 2950744. DOI: 10.3389/fnsys.2010.00041. View

17.

Hamilton J, Furman D, Chang C, Thomason M, Dennis E, Gotlib I . Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination. Biol Psychiatry. 2011; 70(4):327-33. PMC: 3144981. DOI: 10.1016/j.biopsych.2011.02.003. View

18.

Wig G, Schlaggar B, Petersen S . Concepts and principles in the analysis of brain networks. Ann N Y Acad Sci. 2011; 1224:126-146. DOI: 10.1111/j.1749-6632.2010.05947.x. View

19.

Cole M, Anticevic A, Repovs G, Barch D . Variable global dysconnectivity and individual differences in schizophrenia. Biol Psychiatry. 2011; 70(1):43-50. PMC: 3204885. DOI: 10.1016/j.biopsych.2011.02.010. View

20.

Fornito A, Yoon J, Zalesky A, Bullmore E, Carter C . General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance. Biol Psychiatry. 2011; 70(1):64-72. PMC: 4015465. DOI: 10.1016/j.biopsych.2011.02.019. View