Vitamin D in Malaria: More Hypotheses Than Clues

Overview

Journal Heliyon

Specialty Social Sciences

Date 2019 Feb 23

PMID 30793054

Citations 8

Authors

Giulia Bivona

Luisa Agnello

Bruna Lo Sasso

Concetta Scazzone

Daniela Butera

Caterina Maria Gambino

Giorgia Iacolino

Chiara Bellia

Marcello Ciaccio

Affiliations

Soon will be listed here.

Abstract

Vitamin D is a secosteroid hormone regulating calcium and phosphate metabolism, immune response and brain development. Low blood 25(OH)D levels have been reported in patients affected by infectious diseases caused by parasites, including malaria. Despite the high effectiveness of antimalarials, malaria is burdened with high morbidity and mortality, and the search for additional therapies is rapidly growing. Furthermore, available preventive measures have proved to be barely effective so far. Finding new prevention and therapy tools is a matter of urgency. Studies on animal models and humans have hypothesized some mechanisms by which the hormone can influence malaria pathogenesis, and the role of Vitamin D supplementation in preventing and treating this disease has been suggested. Few studies on the association between Vitamin D and malaria are available and disagreeing results have been reported. Studies in humans reporting an association between low 25(OH)D circulating levels and Malaria have a small sample size and observational study-set. Randomized controlled trials are needed in order to understand if Vitamin D administration might play a role in preventing and treating malaria.

Citing Articles

Vitamin D-Dependent Rickets Type 1A in Two Siblings with a Hypomorphic Variant Frequent in the African Population.

de Brito Chagas J, Cordinha C, do Carmo C, Alves C, Heath K, Sousa S J Pediatr Genet. 2024; 13(1):43-49.

PMID: 38567179 PMC: 10984714. DOI: 10.1055/s-0041-1736559.

Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy.

Gomes A, Cunha N, Varela E, Brigido H, Vale V, Dolabela M Int J Mol Sci. 2022; 23(11).

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Characterization of Vitamin D Status in Older Persons with Cognitive Impairment.

Arosio B, Rossi P, Ferri E, Cesari M, Vitale G Nutrients. 2022; 14(6).

PMID: 35334800 PMC: 8949190. DOI: 10.3390/nu14061142.

Mendelian randomization study updates the effect of 25-hydroxyvitamin D levels on the risk of multiple sclerosis.

Wang R J Transl Med. 2022; 20(1):3.

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Micronutrient levels and their effects on the prognosis of visceral leishmaniasis treatment, a prospective cohort study.

Feleke B, Feleke T BMC Infect Dis. 2020; 20(1):867.

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References

Kalinec G, Lomberk G, Urrutia R, Kalinec F . Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss. Front Cell Neurosci. 2017; 11:192. PMC: 5500902. DOI: 10.3389/fncel.2017.00192. View

Ray S, Kamath K, Srivastava R, Raghu D, Gollapalli K, Jain R . Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response. J Proteomics. 2011; 75(10):3063-80. DOI: 10.1016/j.jprot.2011.10.018. View

Gao Q, Fan Y, Mu L, Ma L, Song Z, Zhang Y . S100B and ADMA in cerebral small vessel disease and cognitive dysfunction. J Neurol Sci. 2015; 354(1-2):27-32. DOI: 10.1016/j.jns.2015.04.031. View

Bivona G, Agnello L, Ciaccio M . Vitamin D and Immunomodulation: Is It Time to Change the Reference Values?. Ann Clin Lab Sci. 2017; 47(4):508-510. View

Daley P, Jagannathan V, John K, Sarojini J, Latha A, Vieth R . Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial. Lancet Infect Dis. 2015; 15(5):528-34. DOI: 10.1016/S1473-3099(15)70053-8. View

Autier P, Mullie P, Macacu A, Dragomir M, Boniol M, Coppens K . Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017; 5(12):986-1004. DOI: 10.1016/S2213-8587(17)30357-1. View

Toniato E, Spinas E, Saggini A, Kritas S, Caraffa A, Antinolfi P . IMMUNOMODULATORY EFFECTS OF VITAMIN D ON SKIN INFLAMMATION. J Biol Regul Homeost Agents. 2015; 29(3):563-7. View

Sudfeld C, Giovannucci E, Isanaka S, Aboud S, Mugusi F, Wang M . Vitamin D status and incidence of pulmonary tuberculosis, opportunistic infections, and wasting among HIV-infected Tanzanian adults initiating antiretroviral therapy. J Infect Dis. 2012; 207(3):378-85. PMC: 3537448. DOI: 10.1093/infdis/jis693. View

Nnoaham K, Clarke A . Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol. 2008; 37(1):113-9. DOI: 10.1093/ije/dym247. View

10.

Giulia B, Luisa A, Concetta S, Bruna L, Chiara B, Marcello C . Procalcitonin and community-acquired pneumonia (CAP) in children. Clin Chim Acta. 2015; 451(Pt B):215-8. DOI: 10.1016/j.cca.2015.09.031. View

11.

Ginde A, Mansbach J, Camargo Jr C . Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009; 169(4):384-90. PMC: 3447082. DOI: 10.1001/archinternmed.2008.560. View

12.

Sismanlar T, Tana Aslan A, Gulbahar O, Ozkan S . The effect of vitamin D on lower respiratory tract infections in children. Turk Pediatri Ars. 2016; 51(2):94-9. PMC: 4959747. DOI: 10.5152/TurkPediatriArs.2016.3383. View

13.

Enioutina E, Bareyan D, Daynes R . TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses. J Immunol. 2009; 182(7):4296-305. DOI: 10.4049/jimmunol.0804344. View

14.

Gil A, Plaza-Diaz J, Mesa M . Vitamin D: Classic and Novel Actions. Ann Nutr Metab. 2018; 72(2):87-95. DOI: 10.1159/000486536. View

15.

Wang X, Zhang S, Lin F, Chu W, Yue S . Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer's Disease. Am J Alzheimers Dis Other Demen. 2013; 30(8):729-32. PMC: 10852776. DOI: 10.1177/1533317513495107. View

16.

Wang T, Tavera-Mendoza L, Laperriere D, Libby E, MacLeod N, Nagai Y . Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005; 19(11):2685-95. DOI: 10.1210/me.2005-0106. View

17.

Pavlov V, Tracey K . Neural regulation of immunity: molecular mechanisms and clinical translation. Nat Neurosci. 2017; 20(2):156-166. DOI: 10.1038/nn.4477. View

18.

Hewison M . Antibacterial effects of vitamin D. Nat Rev Endocrinol. 2011; 7(6):337-45. DOI: 10.1038/nrendo.2010.226. View

19.

Vial H, Thuet M, Philippot J . Inhibition of the in vitro growth of Plasmodium falciparum by D vitamins and vitamin D-3 derivatives. Mol Biochem Parasitol. 1982; 5(3):189-98. DOI: 10.1016/0166-6851(82)90020-2. View

20.

Miller J, Harvey D, Beckett L, Green R, Farias S, Reed B . Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults. JAMA Neurol. 2015; 72(11):1295-303. PMC: 5023277. DOI: 10.1001/jamaneurol.2015.2115. View