Model-based Evaluation of Gene Expression Changes in Response to Infection

Overview

Journal Gene Regul Syst Bio

Publisher Sage Publications

Date 2019 Feb 23

PMID 30792575

Citations 4

Authors

Brendan D Stamper

Madison Davis

Sean Scott-Collins

Julie Tran

Caryn Ton

Agapi Simidyan

Sigrid C Roberts

Affiliations

Soon will be listed here.

Abstract

Since the development of high-density microarray technology in the late 1990s, global host gene expression changes in response to various stimuli have been extensively studied. More than a dozen peer-reviewed publications have investigated the effect of infection in various models since 2001. This review covers the transcriptional changes in macrophage models induced by various species and summarizes the resulting impact these studies have on our understanding of the host response to leishmaniasis in vitro. Characterization of the similarities and differences between various model systems will not only further our understanding of -induced changes to macrophage gene expression but also identify potential therapeutic targets in the future.

Citing Articles

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Transcriptional Studies on - Host Cell Interactions: A Complex Puzzle of Variables.

Libisch M, Rego N, Robello C Front Cell Infect Microbiol. 2021; 11:692134.

PMID: 34222052 PMC: 8248493. DOI: 10.3389/fcimb.2021.692134.

Gene expression patterns associated with Leishmania panamensis infection in macrophages from BALB/c and C57BL/6 mice.

Restrepo C, Llanes A, Herrera L, Ellis E, Lleonart R, Fernandez P PLoS Negl Trop Dis. 2021; 15(2):e0009225.

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Phylloseptin-1 is Leishmanicidal for Amastigotes of Inside Infected Macrophages.

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