Association Between ADAM33 Polymorphisms and Asthma Risk: a Systematic Review and Meta-analysis

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2019 Feb 23

PMID 30791911

Citations 11

Authors

Hui-Fang Li

Li-Ping Yan

Kun Wang

Xiao-Tong Li

Hai-Xian Liu

Wei Tan

Affiliations

Soon will be listed here.

Abstract

Background: Asthma is a common complex chronic, inflammatory polygenic disease with heterogeneous manifestations, affecting individuals of all age groups and posing an immense burden on healthcare resources. A number of studies have identified the association between a disintegrin and metalloprotease 33 (ADAM33) polymorphisms and asthma risk, however, the results still remain inconclusive. The objective of the present study was to identify the effect of ADAM33 variants in asthma susceptibility.

Methods: Eligible case-control studies published between January 2000 and June 2018 was searched and retrieved from online electronic databases. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the effect.

Results: A total of 63 case-control studies were finally screened out, including 13,280 asthma patients and 13,340 controls. Eleven SNPs of ADAM33 gene were identified. Our results detected a significant association between ADAM33 T2, Q1, F + 1 and AA genotype of T + 1 polymorphisms and asthma risk in total population. Subgroup analysis by ethnicities showed that the alleles and genotypes of T2, Q1 and F + 1 polymorphisms were associated with asthma susceptibility among Asian populations, while V4 polymorphism was associated with asthma among Caucasian populations. Subgroup analysis by ages showed that T2, F + 1 and ST + 4 polymorphisms were associated with childhood asthma, while Q1 and V4 polymorphisms were associated with asthma risk in adults. Subgroup analysis by asthma severity showed that only the G allele of ADAM33 T1 polymorphism was associated with the severity of asthma when compared with the controls. In addition, T2, Q1 and F + 1 polymorphisms of ADAM33 were significantly associated with increased the asthma risk in Chinese asthma patients.

Conclusions: Our results found that T2, Q1 and F + 1 polymorphisms of ADAM33 gene might contribute to asthma risk. Future well-designed case-control studies with large population and more ethnicities are still needed to estimate the association.

Citing Articles

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Polymorphism in ADAM33 gene associated with asthmatics in West Bengal, India - An investigation by in-silico analysis.

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In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility.

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References

Van Eerdewegh P, Little R, Dupuis J, Mastro R, Falls K, Simon J . Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 2002; 418(6896):426-30. DOI: 10.1038/nature00878. View

Shapiro S, Owen C . ADAM-33 surfaces as an asthma gene. N Engl J Med. 2002; 347(12):936-8. DOI: 10.1056/NEJMcibr022144. View

Powell R, Hamilton L, Holgate S, Davies D, Holloway J . ADAM33: a novel therapeutic target for asthma. Expert Opin Ther Targets. 2003; 7(4):485-94. DOI: 10.1517/14728222.7.4.485. View

Lind D, Choudhry S, Ung N, Ziv E, Avila P, Salari K . ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003; 168(11):1312-6. DOI: 10.1164/rccm.200306-877OC. View

Howard T, Postma D, Jongepier H, Moore W, Koppelman G, Zheng S . Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol. 2003; 112(4):717-22. DOI: 10.1016/s0091-6749(03)01939-0. View

Werner M, Herbon N, Gohlke H, Altmuller J, Knapp M, Heinrich J . Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy. 2004; 34(1):26-31. DOI: 10.1111/j.1365-2222.2004.01846.x. View

Cakebread J, Haitchi H, Holloway J, Powell R, Keith T, Davies D . The role of ADAM33 in the pathogenesis of asthma. Springer Semin Immunopathol. 2004; 25(3-4):361-75. DOI: 10.1007/s00281-003-0153-z. View

Jongepier H, Boezen H, Dijkstra A, Howard T, Vonk J, Koppelman G . Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy. 2004; 34(5):757-60. DOI: 10.1111/j.1365-2222.2004.1938.x. View

Lee J, Park H, Park S, Jang A, Uh S, Rhim T . ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy. 2004; 34(6):860-5. DOI: 10.1111/j.1365-2222.2004.01977.x. View

10.

Holgate S, Davies D, Powell R, Holloway J . ADAM33: a newly identified protease involved in airway remodelling. Pulm Pharmacol Ther. 2005; 19(1):3-11. DOI: 10.1016/j.pupt.2005.02.008. View

11.

Holgate S, Davies D, Powell R, Holloway J . ADAM33: a newly identified gene in the pathogenesis of asthma. Immunol Allergy Clin North Am. 2005; 25(4):655-68. DOI: 10.1016/j.iac.2005.07.003. View

12.

Lee J, Park S, Chang H, Kim H, Rhim T, Lee J . A disintegrin and metalloproteinase 33 protein in patients with asthma: Relevance to airflow limitation. Am J Respir Crit Care Med. 2006; 173(7):729-35. DOI: 10.1164/rccm.200409-1175OC. View

13.

Noguchi E, Ohtsuki Y, Tokunaga K, Yamaoka-Sageshima M, Ichikawa K, Aoki T . ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. Clin Exp Allergy. 2006; 36(5):602-8. DOI: 10.1111/j.1365-2222.2006.02471.x. View

14.

Kedda M, Duffy D, Bradley B, OHehir R, Thompson P . ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet. 2006; 14(9):1027-36. DOI: 10.1038/sj.ejhg.5201662. View

15.

Schedel M, Depner M, Schoen C, Weiland S, Vogelberg C, Niggemann B . The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations. Respir Res. 2006; 7:91. PMC: 1550399. DOI: 10.1186/1465-9921-7-91. View

16.

Holgate S, Yang Y, Haitchi H, Powell R, Holloway J, Yoshisue H . The genetics of asthma: ADAM33 as an example of a susceptibility gene. Proc Am Thorac Soc. 2006; 3(5):440-3. DOI: 10.1513/pats.200603-026AW. View

17.

Hirota T, Hasegawa K, Obara K, Matsuda A, Akahoshi M, Nakashima K . Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy. 2006; 36(7):884-91. DOI: 10.1111/j.1365-2222.2006.02522.x. View

18.

Wang P, Liu Q, Li J, Li H, Wei C, Guo C . Lack of association between ADAM33 gene and asthma in a Chinese population. Int J Immunogenet. 2006; 33(4):303-6. DOI: 10.1111/j.1744-313X.2006.00617.x. View

19.

Martinez F . Genes, environments, development and asthma: a reappraisal. Eur Respir J. 2007; 29(1):179-84. DOI: 10.1183/09031936.00087906. View

20.

Foley S, Mogas A, Olivenstein R, Fiset P, Chakir J, Bourbeau J . Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol. 2007; 119(4):863-71. DOI: 10.1016/j.jaci.2006.12.665. View