Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Feb 23

PMID 30791425

Citations 7

Authors

Ruilong Zhao

Haiyan Lin

Lara Bereza-Malcolm

Elizabeth Clarke

Christopher John Jackson

Meilang Xue

Affiliations

Soon will be listed here.

Abstract

Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing-a complex process involving inflammation, proliferation and remodelling. This review will highlight APC's functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing.

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