Biofabrication and Characterization of Flavonoid-loaded Ag, Au, Au-Ag Bimetallic Nanoparticles Using Seed Extract of the Plant Madhuca Longifolia for the Enhancement in Wound Healing Bio-efficacy

Overview

Journal Prog Biomater

Specialty Biomedical Engineering

Date 2019 Feb 22

PMID 30790231

Citations 6

Authors

Mukti Sharma

Saurabh Yadav

Narayanan Ganesh

Man Mohan Srivastava

Shalini Srivastava

Affiliations

Soon will be listed here.

Abstract

The present communication warrants the presence of significant wound healing bio-efficacy of aq. alc. extract of the seed (49.78%) of the plant Madhuca longifolia. A family of seven flavonoid fractions have been ascertained in the seed aq. alc. extract of the target plant using LCMS-8030 analysis. In vivo wound healing parameters (wound area, wound closure, epithelization period, skin breaking strength and hydroxyproline content) have been examined in Swiss albino mice models. Statistically significant (p < 0.001) enhancement in the wound healing bio-efficacy has been effectively induced using flavonoid-loaded gold: (Mf@AuNp) silver: (Mf@AgNp), and Au-Ag bimetallic: (Mf@Au-AgNp) nanoparticles. Among the biofabricated nano-biomaterials, Mf@AgNp exhibited an exceptional enhancement in the wound healing bio-efficacy (80.33%) attaining almost to the level of reference drug Placentrex (84.02%). All the fabricated nano-biomaterials were thoroughly characterized using UV-Vis, XRD, FE-SEM, TEM, EDX, and DLS. The promising enhancement in the wound healing potential of the nano-biomaterial (Mf@AgNp) has been explained based on the cumulative effects of biological and nanotech parameters. The bio-fabricated (Mf@AgNp) nano-biomaterials using the plant M. longifolia have lustrous prospects for the development of complimentary herbal nanomedicine for scaling-up the wound healing bio-efficacy.

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