Senescence Controls Prostatic Neoplasia Driven by Pten Loss

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2019 Feb 22

PMID 30788414

Citations 6

Authors

Maxime Parisotto

Elise Grelet

Rana El Bizri

Daniel Metzger

Affiliations

Soon will be listed here.

Abstract

We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating Pten-deficient cells undergo replication stress and exhibit a DNA damage response, leading to cell senescence, as seen in oncogene-induced senescence.

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