Comparison of Obstetric Outcomes of Pregnancies After Donor-Oocyte Fertilization and Self-Oocyte Fertilization: A Retrospective Cohort Study

Overview

Journal J Hum Reprod Sci

Date 2019 Feb 22

PMID 30787523

Citations 4

Authors

Vikas Yadav

Priyanka Bakolia

Neena Malhotra

Reeta Mahey

Neeta Singh

Alka Kriplani

Affiliations

Soon will be listed here.

Abstract

Aims: The aim of this study is to evaluate and compare multiple obstetric and perinatal outcomes between donor-oocyte fertilization (IVF) and self-oocyte IVF group.

Settings And Design: This study was done in a tertiary care center with ART unit. This was a retrospective comparative cohort study.

Materials And Methods: The present study comprised all women between 20 and 45 years who conceived from oocyte donation ( = 78) between December 1, 2010, and December 31, 2016, and compared with all women who underwent self-oocyte IVF ( = 112). The process involved controlled ovarian stimulation and retrieval of the donor oocytes, preparation of recipient endometrium, and pregnancy management. Obstetric and perinatal outcomes were compared.

Statistical Analysis Used: Chi-square test was used for categorical variables. Analysis for confounding variables was performed using multivariable linear and logistic regression analysis.

Results: Baseline characteristics between the two groups were comparable. Miscarriage, first-trimester bleeding, pregnancy-induced hypertension (PIH), and gestational diabetes mellitus were significantly higher in donor-oocyte IVF group compared to self-oocyte cycles ( = 0.001). Using multiple logistic regression analysis, age class adjusted PIH incidence was significantly higher in donor-oocyte group as compared to self-oocyte group ( = 0.010). There was no significant variation in perinatal outcomes between the donor- and self-oocyte IVF cycles ( > 0.05).

Conclusion: Oocyte donation should be treated as an independent risk factor for PIH.

Citing Articles

Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis.

Jamshidi Kerachi A, Shahlaee M, Habibi P, Dehdari Ebrahimi N, Ala M, Sadeghi A BMC Med. 2025; 23(1):129.

PMID: 40022113 PMC: 11871686. DOI: 10.1186/s12916-025-03935-0.

Premature ovarian insufficiency.

Touraine P, Chabbert-Buffet N, Plu-Bureau G, Duranteau L, Sinclair A, Tucker E Nat Rev Dis Primers. 2024; 10(1):63.

PMID: 39266563 DOI: 10.1038/s41572-024-00547-5.

A systematic review of reproductive technologies for shared conception in same-sex female couples.

Dubois B, Naveed H, Nietsch K, Band I, Brandao P, Estevez S Fertil Steril. 2024; 122(5):774-782.

PMID: 39260536 PMC: 11560591. DOI: 10.1016/j.fertnstert.2024.09.008.

Comparison of obstetric and perinatal complications in intracytoplasmic sperm injection cycles with autologous oocytes and donated oocytes.

Horta V, de Sa R, Lourenco M, Horta R, Horta R, Maldonado L Rev Assoc Med Bras (1992). 2024; 70(8):e20240357.

PMID: 39166681 PMC: 11329238. DOI: 10.1590/1806-9282.20240357.

Follicular fluid oxidative stress biomarkers and ART outcomes in PCOS women undergoing in vitro fertilization: A cross-sectional study.

Gongadashetti K, Gupta P, Dada R, Malhotra N Int J Reprod Biomed. 2021; 19(5):449-456.

PMID: 34278198 PMC: 8261096. DOI: 10.18502/ijrm.v19i5.9254.

References

Salha O, Sharma V, Dada T, Nugent D, Rutherford A, Tomlinson A . The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod. 1999; 14(9):2268-73. DOI: 10.1093/humrep/14.9.2268. View

Li D, Wi S . Changing paternity and the risk of preeclampsia/eclampsia in the subsequent pregnancy. Am J Epidemiol. 2000; 151(1):57-62. DOI: 10.1093/oxfordjournals.aje.a010122. View

Kavic S, Sauer M . Oocyte donation treats infertility in survivors of malignancies: ten-year experience. J Assist Reprod Genet. 2001; 18(3):181-3. PMC: 3455592. DOI: 10.1023/a:1016605102539. View

Sheffer-Mimouni G, Mashiach S, Dor J, Levran D, Seidman D . Factors influencing the obstetric and perinatal outcome after oocyte donation. Hum Reprod. 2002; 17(10):2636-40. DOI: 10.1093/humrep/17.10.2636. View

Toner J, Grainger D, Frazier L . Clinical outcomes among recipients of donated eggs: an analysis of the U.S. national experience, 1996-1998. Fertil Steril. 2002; 78(5):1038-45. DOI: 10.1016/s0015-0282(02)03371-x. View

Paulson R, Boostanfar R, Saadat P, Mor E, Tourgeman D, Slater C . Pregnancy in the sixth decade of life: obstetric outcomes in women of advanced reproductive age. JAMA. 2002; 288(18):2320-3. DOI: 10.1001/jama.288.18.2320. View

Karnis M, Zimon A, Lalwani S, Timmreck L, Klipstein S, Reindollar R . Risk of death in pregnancy achieved through oocyte donation in patients with Turner syndrome: a national survey. Fertil Steril. 2003; 80(3):498-501. DOI: 10.1016/s0015-0282(03)00974-9. View

Wiggins D, Main E . Outcomes of pregnancies achieved by donor egg in vitro fertilization--a comparison with standard in vitro fertilization pregnancies. Am J Obstet Gynecol. 2005; 192(6):2002-6. DOI: 10.1016/j.ajog.2005.02.059. View

Simchen M, Yinon Y, Moran O, Schiff E, Sivan E . Pregnancy outcome after age 50. Obstet Gynecol. 2006; 108(5):1084-8. DOI: 10.1097/01.AOG.0000240139.46018.bd. View

10.

Krieg S, Henne M, Westphal L . Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies. Fertil Steril. 2007; 90(1):65-70. DOI: 10.1016/j.fertnstert.2007.06.014. View

11.

Gundogan F, Bianchi D, Scherjon S, Roberts D . Placental pathology in egg donor pregnancies. Fertil Steril. 2009; 93(2):397-404. DOI: 10.1016/j.fertnstert.2008.12.144. View

12.

Braat D, Schutte J, Bernardus R, Mooij T, van Leeuwen F . Maternal death related to IVF in the Netherlands 1984-2008. Hum Reprod. 2010; 25(7):1782-6. DOI: 10.1093/humrep/deq080. View

13.

Klatsky P, Delaney S, Caughey A, Tran N, Schattman G, Rosenwaks Z . The role of embryonic origin in preeclampsia: a comparison of autologous in vitro fertilization and ovum donor pregnancies. Obstet Gynecol. 2010; 116(6):1387-1392. DOI: 10.1097/AOG.0b013e3181fb8e59. View

14.

van der Hoorn M, Scherjon S, Claas F . Egg donation pregnancy as an immunological model for solid organ transplantation. Transpl Immunol. 2011; 25(2-3):89-95. DOI: 10.1016/j.trim.2011.06.004. View

15.

Le Ray C, Scherier S, Anselem O, Marszalek A, Tsatsaris V, Cabrol D . Association between oocyte donation and maternal and perinatal outcomes in women aged 43 years or older. Hum Reprod. 2012; 27(3):896-901. DOI: 10.1093/humrep/der469. View

16.

Laskov I, Birnbaum R, Maslovitz S, Kupferminc M, Lessing J, Many A . Outcome of singleton pregnancy in women ≥ 45 years old: a retrospective cohort study. J Matern Fetal Neonatal Med. 2012; 25(11):2190-3. DOI: 10.3109/14767058.2012.684108. View

17.

Taglauer E, Gundogan F, Johnson K, Scherjon S, Bianchi D . Chorionic plate expression patterns of the maspin tumor suppressor protein in preeclamptic and egg donor placentas. Placenta. 2013; 34(4):385-7. DOI: 10.1016/j.placenta.2013.01.008. View

18.

Tranquilli A, Biondini V, Talebi Chahvar S, Corradetti A, Tranquilli D, Giannubilo S . Perinatal outcomes in oocyte donor pregnancies. J Matern Fetal Neonatal Med. 2013; 26(13):1263-7. DOI: 10.3109/14767058.2013.777422. View

19.

Malchau S, Loft A, Larsen E, Henningsen A, Rasmussen S, Nyboe Andersen A . Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study. Fertil Steril. 2013; 99(6):1637-43. DOI: 10.1016/j.fertnstert.2013.01.128. View

20.

Kawwass J, Monsour M, Crawford S, Kissin D, Session D, Kulkarni A . Trends and outcomes for donor oocyte cycles in the United States, 2000-2010. JAMA. 2013; 310(22):2426-34. PMC: 4307377. DOI: 10.1001/jama.2013.280924. View