Modeling and Simulation of Phototransduction Cascade in Vertebrate Rod Photoreceptors

Overview

Journal BMC Ophthalmol

Publisher Biomed Central

Specialty Ophthalmology

Date 2019 Feb 22

PMID 30786871

Citations 1

Authors

Guofeng Pan

Jinglu Tan

Ya Guo

Affiliations

Soon will be listed here.

Abstract

Background: The activation of phototransduction cascade in rod photoreceptors has been well studied in literature, but there is a lack of a mature kinetic model structure covering both the activation and inactivation processes.

Methods: In this work, a kinetic model structure is developed to describe the major activation and inactivation processes in vertebrate rod photoreceptors with the electroretinogram (ERG) as output. Simulation was performed to validate developed model structure.

Results: The developed model structure could fit experimental data with small error.

Conclusions: The result indicated that the developed model structure could show the inactivation process of phototransduction cascades in the rod photoreceptors.

Citing Articles

Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation.

Grini J, Nygard M, Ruoff P PLoS One. 2023; 18(4):e0281490.

PMID: 37115760 PMC: 10146485. DOI: 10.1371/journal.pone.0281490.

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