The Effects of N-acetylcysteine on Radiotherapy-induced Small Intestinal Damage in Rats

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2019 Feb 22

PMID 30786762

Citations 4

Authors

Filiz Mercantepe

Atilla Topcu

Sema Rakici

Levent Tumkaya

Adnan Yilmaz

Affiliations

Soon will be listed here.

Abstract

Some six million cancer patients currently receive radiotherapy. Radiotherapy eliminates cancer cells by accelerating their death. However, radiotherapy is not selective, and it therefore harms healthy tissues around cancerous tissue. The latest studies have shown that the irradiation of biological materials causes a rapid increase in reactive oxygen species (ROS) in the tissue as a result of exposure of the target molecule to direct and indirect ionization. N-acetylcysteine (NAC) is an antioxidant that permits the elimination of free oxygen radicals and that contributes to glutathione synthesis. Our study, therefore, examined the effects of radiation resulting from radiotherapy on the small intestine at the molecular level, and prospectively considered the potential protective characteristics of NAC against gastrointestinal syndrome resulting from radiotherapy.

Citing Articles

Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies.

Lu Q, Liang Y, Tian S, Jin J, Zhao Y, Fan H Toxics. 2023; 11(12).

PMID: 38133412 PMC: 10747544. DOI: 10.3390/toxics11121011.

Dose- and Segment-Dependent Disturbance of Rat Gut by Ionizing Radiation: Impact of Tight Junction Proteins.

Livanova A, Fedorova A, Zavirsky A, Krivoi I, Markov A Int J Mol Sci. 2023; 24(2).

PMID: 36675266 PMC: 9863103. DOI: 10.3390/ijms24021753.

Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms.

Chen G, Han Y, Zhang H, Tu W, Zhang S Front Oncol. 2021; 11:757973.

PMID: 34804953 PMC: 8604098. DOI: 10.3389/fonc.2021.757973.

The radioprotective effect of N-acetylcysteine against x-radiation-induced renal injury in rats.

Mercantepe T, Topcu A, Rakici S, Tumkaya L, Yilmaz A, Mercantepe F Environ Sci Pollut Res Int. 2019; 26(28):29085-29094.

PMID: 31392607 DOI: 10.1007/s11356-019-06110-0.

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