Correlation of Serum Vitamin D Levels in Lactating Mothers and Their Infants

Overview

Journal Indian J Endocrinol Metab

Specialty Endocrinology

Date 2019 Feb 16

PMID 30766822

Citations 1

Authors

Minhaz Husain

Manish Verma

Rakesh Jora

Jai Prakash Soni

Pramod Sharma

Affiliations

Soon will be listed here.

Abstract

Background: Although Vitamin D deficiency is highly prevalent in Indians, data on Vitamin D eficiency in lactating mothers and exclusively breast fed infants is inadequate.

Objective: This study was done to evaluate the prevalence of Vitamin D deficiency in lactating mothers and their infants and to find out any correlation between them.

Materials And Methods: This hospital based, cross sectional study included 200 healthy infants between 1-30 days and their mothers. Serum sample was collected from both for Ca, inorganic phosphate (IP), alkaline phosphatase (ALP), and 25(OH)D.

Results: Mean serum 25(OH)D level of mothers was 11.33 ± 5.86 ng/ml with a range of 2-37 ng/ml. Hypovitaminosis D was defined as serum 25(OH)D level <10 ng/ml. Almost 94 (47%) of mothers were having hypovitaminosis D. Mean serum 25(OH)D level of infants was 11.92 ± 7.89 ng/dl with a range of 2.5-68 ng/dl. Ninety (45%) infants were having hypovitaminosis D. There was a moderate positive correlation between individual mothers' and infants' serum 25(OH)D values (Pearson coefficient = 0.516, < 0.001). Using logistic regression, it was found that infants born to mothers with hypovitaminosis D carry a 4.47 times more risk of developing hypovitaminosis D as compared to infants born to mothers with normal serum 25(OH)D (Odds ratio = 4.47, < 0.001).

Conclusion: This study shows a high prevalence of Vitamin D deficiency in lactating mothers and their breastfeeding infants with a positive correlation between them. These results provide a justification for adequate Vitamin D supplementation of all exclusively breastfeeding infants and highlight the urgent need to improve maternal Vitamin D status.

Citing Articles

Correlation of serum levels of Vitamin D with serum parathormone in nursing mothers and infants 1-6 months' age from South Punjab, Pakistan.

Mustafa G, Khalid M, Ahmed I, Talib M Pak J Med Sci. 2020; 36(5):1015-1019.

PMID: 32704281 PMC: 7372660. DOI: 10.12669/pjms.36.5.2150.

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