Determination of Medication Adherence and Related Factors Among People Living with HIV/AIDS in a Turkish University Hospital

Overview

Journal Turk J Med Sci

Specialty General Medicine

Date 2019 Feb 16

PMID 30764598

Citations 4

Authors

Erdal Ceylan

Aysegul Koc

Ahmet Cagkan Inkaya

Serhat Unal

Affiliations

Soon will be listed here.

Abstract

Background/aim: Widespread use of antiretroviral treatment (ART) has led to decrease in the incidence of HIV/AIDS-related mortality. Besides the availability of ART, medication adherence is essential for treatment success. There is a scarcity of data reported from Turkey regarding ART adherence among people living with HIV/AIDS (PLWHA). Therefore, this study was undertaken to determine medication adherence and related factors among PLWHA in Turkey.

Materials And Methods: The sample consisted of 158 PLWHA, who were being followed up at Infectious Diseases Outpatient Clinic of Hacettepe University Hospital. Data were collected using an individual questionnaire and the Turkish version of the Morisky Medication Adherence Scale.

Results: The median patient age was 38 years, 80.4% were male, and 51.3% were married. The median duration of both HIV infection and ART was 3 years. Sixty-one percent used two drug regimens. Sixty-one percent were highly adherent to ART while 37.9% were moderately adherent. The absence/presence of social support resources, disease duration, ART duration, and being informed about the ART regimen were statistically associated with medication adherence.

Conclusion: Our results suggest that medication adherence is excellent among Turkish PLWHA. Interventions, including effective social support, and continuous counseling about ART, might further boost the adherence of PLWHA

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References

Kalichman S, Grebler T . Stress and poverty predictors of treatment adherence among people with low-literacy living with HIV/AIDS. Psychosom Med. 2010; 72(8):810-6. PMC: 3016469. DOI: 10.1097/PSY.0b013e3181f01be3. View

Hansana V, Sanchaisuriya P, Durham J, Sychareun V, Chaleunvong K, Boonyaleepun S . Adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV): a cross-sectional survey to measure in Lao PDR. BMC Public Health. 2013; 13:617. PMC: 3707741. DOI: 10.1186/1471-2458-13-617. View

Kumarasamy N, Patel A, Pujari S . Antiretroviral therapy in Indian setting: when & what to start with, when & what to switch to?. Indian J Med Res. 2012; 134(6):787-800. PMC: 3284090. DOI: 10.4103/0971-5916.92626. View

Cihlar T, Fordyce M . Current status and prospects of HIV treatment. Curr Opin Virol. 2016; 18:50-6. DOI: 10.1016/j.coviro.2016.03.004. View

Kalichman S, Ramachandran B, Catz S . Adherence to combination antiretroviral therapies in HIV patients of low health literacy. J Gen Intern Med. 1999; 14(5):267-73. PMC: 1496573. DOI: 10.1046/j.1525-1497.1999.00334.x. View

Joshi B, Chauhan S, Pasi A, Kulkarni R, Sunil N, Bachani D . Level of suboptimal adherence to first line antiretroviral treatment & its determinants among HIV positive people in India. Indian J Med Res. 2014; 140(1):84-95. PMC: 4181166. View

Waite K, Paasche-Orlow M, Rintamaki L, Davis T, Wolf M . Literacy, social stigma, and HIV medication adherence. J Gen Intern Med. 2008; 23(9):1367-72. PMC: 2518013. DOI: 10.1007/s11606-008-0662-5. View

Letta S, Demissie A, Oljira L, Dessie Y . Factors associated with adherence to Antiretroviral Therapy (ART) among adult people living with HIV and attending their clinical care, Eastern Ethiopia. BMC Int Health Hum Rights. 2015; 15:33. PMC: 4693416. DOI: 10.1186/s12914-015-0071-x. View

Atuyambe L, Neema S, Otolok-Tanga E, Wamuyu-Maina G, Kasasa S, Wabwire-Mangen F . The effects of enhanced access to antiretroviral therapy: a qualitative study of community perceptions in Kampala city, Uganda. Afr Health Sci. 2009; 8(1):13-9. PMC: 2408540. View

10.

Bezabhe W, Chalmers L, Bereznicki L, Peterson G, Bimirew M, Kassie D . Barriers and facilitators of adherence to antiretroviral drug therapy and retention in care among adult HIV-positive patients: a qualitative study from Ethiopia. PLoS One. 2014; 9(5):e97353. PMC: 4020856. DOI: 10.1371/journal.pone.0097353. View

11.

Genberg B, Lee Y, Rogers W, Wilson I . Four types of barriers to adherence of antiretroviral therapy are associated with decreased adherence over time. AIDS Behav. 2014; 19(1):85-92. PMC: 4203705. DOI: 10.1007/s10461-014-0775-2. View

12.

Morrison S, Rashidi V, Sarnquist C, Banushi V, Hole M, Barbhaiya N . Antiretroviral therapy adherence and predictors to adherence in Albania: a cross-sectional study. J Infect Dev Ctries. 2014; 8(7):853-62. DOI: 10.3855/jidc.3563. View

13.

Holtzman C, Shea J, Glanz K, Jacobs L, Gross R, Hines J . Mapping patient-identified barriers and facilitators to retention in HIV care and antiretroviral therapy adherence to Andersen's Behavioral Model. AIDS Care. 2015; 27(7):817-28. PMC: 4400221. DOI: 10.1080/09540121.2015.1009362. View

14.

Tran B, Nguyen L, Nguyen N, Hoang Q, Hwang J . Determinants of antiretroviral treatment adherence among HIV/AIDS patients: a multisite study. Glob Health Action. 2013; 6:19570. PMC: 3600425. DOI: 10.3402/gha.v6i0.19570. View

15.

Intasan J, Bunupuradah T, Vonthanak S, Kosalaraksa P, Hansudewechakul R, Kanjanavanit S . Comparison of adherence monitoring tools and correlation to virologic failure in a pediatric HIV clinical trial. AIDS Patient Care STDS. 2014; 28(6):296-302. PMC: 4046210. DOI: 10.1089/apc.2013.0276. View

16.

Liu A, Hessol N, Vittinghoff E, Amico K, Kroboth E, Fuchs J . Medication adherence among men who have sex with men at risk for HIV infection in the United States: implications for pre-exposure prophylaxis implementation. AIDS Patient Care STDS. 2014; 28(12):622-7. PMC: 4250955. DOI: 10.1089/apc.2014.0195. View

17.

Talam N, Gatongi P, Rotich J, Kimaiyo S . Factors affecting antiretroviral drug adherence among HIV/AIDS adult patients attending HIV/AIDS clinic at Moi Teaching and Referral Hospital, Eldoret, Kenya. East Afr J Public Health. 2008; 5(2):74-8. View

18.

Kibicho J, Owczarzak J . Pharmacists' strategies for promoting medication adherence among patients with HIV. J Am Pharm Assoc (2003). 2011; 51(6):746-55. PMC: 4371784. DOI: 10.1331/JAPhA.2011.10190. View

19.

Chandwani S, Koenig L, Sill A, Abramowitz S, Conner L, DAngelo L . Predictors of antiretroviral medication adherence among a diverse cohort of adolescents with HIV. J Adolesc Health. 2012; 51(3):242-51. DOI: 10.1016/j.jadohealth.2011.12.013. View

20.

Sax P, Meyers J, Mugavero M, Davis K . Adherence to antiretroviral treatment and correlation with risk of hospitalization among commercially insured HIV patients in the United States. PLoS One. 2012; 7(2):e31591. PMC: 3286454. DOI: 10.1371/journal.pone.0031591. View