RNA 2'-O-Methylation (Nm) Modification in Human Diseases

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2019 Feb 16

PMID 30764532

Citations 94

Authors

Dilyana G Dimitrova

Laure Teysset

Clement Carre

Affiliations

Soon will be listed here.

Abstract

Nm (2'-O-methylation) is one of the most common modifications in the RNA world. It has the potential to influence the RNA molecules in multiple ways, such as structure, stability, and interactions, and to play a role in various cellular processes from epigenetic gene regulation, through translation to self versus non-self recognition. Yet, building scientific knowledge on the Nm matter has been hampered for a long time by the challenges in detecting and mapping this modification. Today, with the latest advancements in the area, more and more Nm sites are discovered on RNAs (tRNA, rRNA, mRNA, and small non-coding RNA) and linked to normal or pathological conditions. This review aims to synthesize the Nm-associated human diseases known to date and to tackle potential indirect links to some other biological defects.

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