Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Feb 16

PMID 30764493

Citations 14

Authors

Grace C A Manley

Lisa C Parker

Yongliang Zhang

Affiliations

Soon will be listed here.

Abstract

Inflammatory airway disease, such as asthma and chronic obstructive pulmonary disease (COPD), is a major health burden worldwide. These diseases cause large numbers of deaths each year due to airway obstruction, which is exacerbated by respiratory viral infection. The inflammatory response in the airway is mediated in part through the MAPK pathways: p38, JNK and ERK. These pathways also have roles in interferon production, viral replication, mucus production, and T cell responses, all of which are important processes in inflammatory airway disease. Dual-specificity phosphatases (DUSPs) are known to regulate the MAPKs, and roles for this family of proteins in the pathogenesis of airway disease are emerging. This review summarizes the function of DUSPs in regulation of cytokine expression, mucin production, and viral replication in the airway. The central role of DUSPs in T cell responses, including T cell activation, differentiation, and proliferation, will also be highlighted. In addition, the importance of this protein family in the lung, and the necessity of further investigation into their roles in airway disease, will be discussed.

Citing Articles

Revealing the Mechanisms of Qilongtian Capsules in the Treatment of Chronic Obstructive Pulmonary Disease Based on Integrated Network Pharmacology, Molecular Docking, and Experiments.

Xie Y, Li Z, Liang Y, Zhou T, Yuan X, Su X ACS Omega. 2024; 9(30):32455-32468.

PMID: 39100362 PMC: 11292813. DOI: 10.1021/acsomega.3c10163.

MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis.

Talreja J, Peng C, Samavati L iScience. 2024; 27(1):108746.

PMID: 38299032 PMC: 10829885. DOI: 10.1016/j.isci.2023.108746.

Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway.

Yu Y, Yang A, He X, Wu B, Wu Y, Li Y J Inflamm (Lond). 2023; 20(1):36.

PMID: 37915073 PMC: 10621191. DOI: 10.1186/s12950-023-00361-y.

Single-cell RNA sequencing reveals the transcriptomic characteristics of peripheral blood mononuclear cells in hepatitis B vaccine non-responders.

Zhao M, Wang C, Li P, Sun T, Wang J, Zhang S Front Immunol. 2023; 14:1091237.

PMID: 37593735 PMC: 10431960. DOI: 10.3389/fimmu.2023.1091237.

RSV replication modifies the XBP1s binding complex on the IRF1 upstream enhancer to potentiate the mucosal anti-viral response.

Qiao D, Xu X, Zhang Y, Yang J, Brasier A Front Immunol. 2023; 14:1197356.

PMID: 37564646 PMC: 10411192. DOI: 10.3389/fimmu.2023.1197356.

References

Londhe V, McNamara N, Lemjabbar H, Basbaum C . Viral dsRNA activates mucin transcription in airway epithelial cells. FEBS Lett. 2003; 553(1-2):33-8. DOI: 10.1016/s0014-5793(03)00863-9. View

Gern J, French D, Grindle K, Brockman-Schneider R, Konno S, Busse W . Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells. Am J Respir Cell Mol Biol. 2003; 28(6):731-7. DOI: 10.1165/rcmb.2002-0055OC. View

Sykes A, Macintyre J, Edwards M, Del Rosario A, Haas J, Gielen V . Rhinovirus-induced interferon production is not deficient in well controlled asthma. Thorax. 2013; 69(3):240-6. DOI: 10.1136/thoraxjnl-2012-202909. View

Message S, Laza-Stanca V, Mallia P, Parker H, Zhu J, Kebadze T . Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci U S A. 2008; 105(36):13562-7. PMC: 2528869. DOI: 10.1073/pnas.0804181105. View

Becker Y . Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy--a review. Virus Genes. 2006; 33(2):235-52. DOI: 10.1007/s11262-006-0064-x. View

Golebski K, Luiten S, van Egmond D, de Groot E, Roschmann K, Fokkens W . High degree of overlap between responses to a virus and to the house dust mite allergen in airway epithelial cells. PLoS One. 2014; 9(2):e87768. PMC: 3912021. DOI: 10.1371/journal.pone.0087768. View

Rohde G, Wiethege A, Borg I, Kauth M, Bauer T, Gillissen A . Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. Thorax. 2003; 58(1):37-42. PMC: 1746460. DOI: 10.1136/thorax.58.1.37. View

Bochkov Y, Hanson K, Keles S, Brockman-Schneider R, Jarjour N, Gern J . Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol. 2009; 3(1):69-80. PMC: 2884103. DOI: 10.1038/mi.2009.109. View

Huang G, Wang Y, Shi L, Kanneganti T, Chi H . Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity. 2011; 35(1):45-58. PMC: 3142929. DOI: 10.1016/j.immuni.2011.05.014. View

10.

Broide D, Lotz M, Cuomo A, Coburn D, Federman E, Wasserman S . Cytokines in symptomatic asthma airways. J Allergy Clin Immunol. 1992; 89(5):958-67. DOI: 10.1016/0091-6749(92)90218-q. View

11.

Heymann P, Carper H, Murphy D, Platts-Mills T, Patrie J, McLaughlin A . Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol. 2004; 114(2):239-47. PMC: 7185400. DOI: 10.1016/j.jaci.2004.04.006. View

12.

Wang M, Gao P, Wu X, Chen Y, Feng Y, Yang Q . Impaired anti-inflammatory action of glucocorticoid in neutrophil from patients with steroid-resistant asthma. Respir Res. 2016; 17(1):153. PMC: 5112750. DOI: 10.1186/s12931-016-0462-0. View

13.

Kwak S, Hakes D, Martell K, Dixon J . Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. J Biol Chem. 1994; 269(5):3596-604. View

14.

Wang X, Lau C, Wiehler S, Pow A, Mazzulli T, Gutierrez C . Syk is downstream of intercellular adhesion molecule-1 and mediates human rhinovirus activation of p38 MAPK in airway epithelial cells. J Immunol. 2006; 177(10):6859-70. DOI: 10.4049/jimmunol.177.10.6859. View

15.

Preugschas H, Hrincius E, Mewis C, Tran G, Ludwig S, Ehrhardt C . Late activation of the Raf/MEK/ERK pathway is required for translocation of the respiratory syncytial virus F protein to the plasma membrane and efficient viral replication. Cell Microbiol. 2018; 21(1):e12955. DOI: 10.1111/cmi.12955. View

16.

Khetsuriani N, Kazerouni N, Erdman D, Lu X, Redd S, Anderson L . Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol. 2006; 119(2):314-21. PMC: 7112359. DOI: 10.1016/j.jaci.2006.08.041. View

17.

Crotty Alexander L, Shin S, Hwang J . Inflammatory Diseases of the Lung Induced by Conventional Cigarette Smoke: A Review. Chest. 2015; 148(5):1307-1322. DOI: 10.1378/chest.15-0409. View

18.

Xia Y, Radwan A, Keenan C, Langenbach S, Li M, Radojicic D . Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-β Activity. PLoS Pathog. 2017; 13(1):e1006138. PMC: 5234851. DOI: 10.1371/journal.ppat.1006138. View

19.

Giembycz M, Newton R . Beyond the dogma: novel beta2-adrenoceptor signalling in the airways. Eur Respir J. 2006; 27(6):1286-306. DOI: 10.1183/09031936.06.00112605. View

20.

McCaskill J, Ressel S, Alber A, Redford J, Power U, Schwarze J . Broad-Spectrum Inhibition of Respiratory Virus Infection by MicroRNA Mimics Targeting p38 MAPK Signaling. Mol Ther Nucleic Acids. 2017; 7:256-266. PMC: 5415959. DOI: 10.1016/j.omtn.2017.03.008. View