The Linear No-Threshold (LNT) Dose Response Model: A Comprehensive Assessment of Its Historical and Scientific Foundations

Overview

Journal Chem Biol Interact

Publisher Elsevier

Specialties Biochemistry
Molecular Biology
Pharmacology

Date 2019 Feb 15

PMID 30763547

Citations 21

Authors

Edward J Calabrese

Affiliations

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Abstract

The linear no-threshold (LNT) single-hit (SH) dose response model for cancer risk assessment is comprehensively assessed with respect to its historical foundations. This paper also examines how mistakes, ideological biases, and scientific misconduct by key scientists affected the acceptance, validity, and applications of the LNT model for cancer risk assessment. In addition, the analysis demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and for risk communication.

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