Neural Correlates of Interval Timing Deficits in Schizophrenia

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2019 Feb 15

PMID 30760991

Citations 9

Authors

Ariel W Snowden

Catalin V Buhusi

Affiliations

Soon will be listed here.

Abstract

Previous research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timing impairments, there is limited focus on the neural correlates of timing in SZ. The neuroimaging literature included in the current review reports hypoactivation in the dorsal-lateral prefrontal cortex (DLPFC), supplementary motor area (SMA) and the basal ganglia (BG). Timing deficits and deficits in attention and working memory (WM) in SZ are likely due to a dysfunction of dopamine (DA) and gamma-aminobutyric acid (GABA) neurotransmission in the cortico-striatal-thalamo-cortical circuits, which are highly implicated in executive functioning and motor preparation.

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References

Schubotz R, Friederici A, von Cramon D . Time perception and motor timing: a common cortical and subcortical basis revealed by fMRI. Neuroimage. 2000; 11(1):1-12. DOI: 10.1006/nimg.1999.0514. View

Volz H, Nenadic I, Gaser C, Rammsayer T, Hager F, Sauer H . Time estimation in schizophrenia: an fMRI study at adjusted levels of difficulty. Neuroreport. 2001; 12(2):313-6. DOI: 10.1097/00001756-200102120-00026. View

Rao S, Mayer A, Harrington D . The evolution of brain activation during temporal processing. Nat Neurosci. 2001; 4(3):317-23. DOI: 10.1038/85191. View

Barch D, Carter C, Braver T, Sabb F, MacDonald 3rd A, Noll D . Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch Gen Psychiatry. 2001; 58(3):280-8. DOI: 10.1001/archpsyc.58.3.280. View

Meyer-Lindenberg A, Miletich R, Kohn P, Esposito G, Carson R, Quarantelli M . Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat Neurosci. 2002; 5(3):267-71. DOI: 10.1038/nn804. View

Buhusi C, Meck W . Differential effects of methamphetamine and haloperidol on the control of an internal clock. Behav Neurosci. 2002; 116(2):291-7. DOI: 10.1037//0735-7044.116.2.291. View

Nenadic I, Gaser C, Volz H, Rammsayer T, Hager F, Sauer H . Processing of temporal information and the basal ganglia: new evidence from fMRI. Exp Brain Res. 2003; 148(2):238-46. DOI: 10.1007/s00221-002-1188-4. View

Koch G, Oliveri M, Torriero S, Caltagirone C . Underestimation of time perception after repetitive transcranial magnetic stimulation. Neurology. 2003; 60(11):1844-6. DOI: 10.1212/wnl.60.11.1844. View

Haggard P, Martin F, Taylor-Clarke M, Jeannerod M, Franck N . Awareness of action in schizophrenia. Neuroreport. 2003; 14(7):1081-5. DOI: 10.1097/01.wnr.0000073684.00308.c0. View

10.

Ferrandez A, Hugueville L, Lehericy S, Poline J, Marsault C, Pouthas V . Basal ganglia and supplementary motor area subtend duration perception: an fMRI study. Neuroimage. 2003; 19(4):1532-44. DOI: 10.1016/s1053-8119(03)00159-9. View

11.

Curtis C, DEsposito M . Persistent activity in the prefrontal cortex during working memory. Trends Cogn Sci. 2003; 7(9):415-423. DOI: 10.1016/s1364-6613(03)00197-9. View

12.

Coull J, Vidal F, Nazarian B, Macar F . Functional anatomy of the attentional modulation of time estimation. Science. 2004; 303(5663):1506-8. DOI: 10.1126/science.1091573. View

13.

Jones C, Rosenkranz K, Rothwell J, Jahanshahi M . The right dorsolateral prefrontal cortex is essential in time reproduction: an investigation with repetitive transcranial magnetic stimulation. Exp Brain Res. 2004; 158(3):366-72. DOI: 10.1007/s00221-004-1912-3. View

14.

Matell M, Meck W . Cortico-striatal circuits and interval timing: coincidence detection of oscillatory processes. Brain Res Cogn Brain Res. 2004; 21(2):139-70. DOI: 10.1016/j.cogbrainres.2004.06.012. View

15.

Hinton S, Meck W . Frontal-striatal circuitry activated by human peak-interval timing in the supra-seconds range. Brain Res Cogn Brain Res. 2004; 21(2):171-82. DOI: 10.1016/j.cogbrainres.2004.08.005. View

16.

Macar F, Anton J, Bonnet M, Vidal F . Timing functions of the supplementary motor area: an event-related fMRI study. Brain Res Cogn Brain Res. 2004; 21(2):206-15. DOI: 10.1016/j.cogbrainres.2004.01.005. View

17.

Koch G, Oliveri M, Brusa L, Stanzione P, Torriero S, Caltagirone C . High-frequency rTMS improves time perception in Parkinson disease. Neurology. 2004; 63(12):2405-6. DOI: 10.1212/01.wnl.0000147336.19972.82. View

18.

Ortuno F, Lopez P, Ojeda N, Cervera S . Dysfunctional supplementary motor area implication during attention and time estimation tasks in schizophrenia: a PET-O15 water study. Neuroimage. 2005; 24(2):575-9. DOI: 10.1016/j.neuroimage.2004.09.010. View

19.

Lewis D, Hashimoto T, Volk D . Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci. 2005; 6(4):312-24. DOI: 10.1038/nrn1648. View

20.

Franck N, Posada A, Pichon S, Haggard P . Altered subjective time of events in schizophrenia. J Nerv Ment Dis. 2005; 193(5):350-3. DOI: 10.1097/01.nmd.0000161699.76032.09. View