Neuroblastoma-A Neural Crest Derived Embryonal Malignancy

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2019 Feb 15

PMID 30760980

Citations 112

Authors

John Inge Johnsen

Cecilia Dyberg

Malin Wickstrom

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity with a disease spectrum ranging from spontaneous regression without any medical intervention to treatment resistant tumors with metastatic spread and poor patient survival. The events that lead to the development of neuroblastoma from the neural crest have not been fully elucidated. Here we discuss factors and processes within the neural crest that when dysregulated have the potential to be initiators or drivers of neuroblastoma development. A more precise biological understanding of neuroblastoma causes and cell of origin is highly warranted. This will give valuable information for the development of medicines that specifically target molecules within neuroblastoma cells and also give hint about the mechanisms behind treatment resistance that is frequently seen in neuroblastoma.

Citing Articles

Loss of ARID1A leads to a cold tumor phenotype via suppression of IFNγ signaling.

Watson P, DeVaux C, Freeman K Sci Rep. 2025; 15(1):8716.

PMID: 40082458 PMC: 11906763. DOI: 10.1038/s41598-025-91688-4.

Silencing YTHDF2 Induces Apoptosis of Neuroblastoma Cells In a Cell Line-Dependent Manner via Regulating the Expression of DLK1.

Hua Z, Gong B, Li Z Mol Neurobiol. 2025; .

PMID: 39979690 DOI: 10.1007/s12035-025-04759-y.

Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy.

Cheng J, Sun M, Dong X, Yang Y, Qin X, Zhou X BMC Cancer. 2025; 25(1):161.

PMID: 39875895 PMC: 11773968. DOI: 10.1186/s12885-025-13560-y.

Synergistic machine learning models utilizing ferroptosis-related genes for improved neuroblastoma outcome prediction.

Cheng J, Dong X, Yang Y, Qin X, Zhou X, Zhang D Transl Pediatr. 2025; 13(12):2164-2182.

PMID: 39822999 PMC: 11732634. DOI: 10.21037/tp-24-323.

Systematic Analysis of miR-506-3p Target Genes Identified Key Mediators of Its Differentiation-Inducing Function.

Cardus D, Smith M, Vernaza A, Smith J, Del Buono B, Parajuli A Genes (Basel). 2024; 15(10).

PMID: 39457392 PMC: 11507652. DOI: 10.3390/genes15101268.

References

Pattyn A, Morin X, Cremer H, Goridis C, Brunet J . The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature. 1999; 399(6734):366-70. DOI: 10.1038/20700. View

Howard M, Stanke M, Schneider C, Wu X, Rohrer H . The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification. Development. 2000; 127(18):4073-81. DOI: 10.1242/dev.127.18.4073. View

Yuan J, Yankner B . Apoptosis in the nervous system. Nature. 2000; 407(6805):802-9. DOI: 10.1038/35037739. View

Tang X, Zhao H, Robinson M, Cnaan A, LONDON W, Cohn S . Prognostic significance of EPHB6, EFNB2, and EFNB3 expressions in neuroblastoma. Med Pediatr Oncol. 2000; 35(6):656-8. DOI: 10.1002/1096-911x(20001201)35:6<656::aid-mpo37>3.0.co;2-a. View

Wong K, Ren X, Huang Y, Xie Y, Liu G, Saito H . Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell. 2001; 107(2):209-21. DOI: 10.1016/s0092-8674(01)00530-x. View

Wartiovaara K, Barnabe-Heider F, Miller F, Kaplan D . N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci. 2002; 22(3):815-24. PMC: 6758514. View

Schilling F, Spix C, Berthold F, Erttmann R, Fehse N, Hero B . Neuroblastoma screening at one year of age. N Engl J Med. 2002; 346(14):1047-53. DOI: 10.1056/NEJMoa012277. View

Brodeur G . Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 2003; 3(3):203-16. DOI: 10.1038/nrc1014. View

Riento K, Ridley A . Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol. 2003; 4(6):446-56. DOI: 10.1038/nrm1128. View

10.

Baker R, Antin P . Ephs and ephrins during early stages of chick embryogenesis. Dev Dyn. 2003; 228(1):128-42. DOI: 10.1002/dvdy.10354. View

11.

Beckwith J, PERRIN E . IN SITU NEUROBLASTOMAS: A CONTRIBUTION TO THE NATURAL HISTORY OF NEURAL CREST TUMORS. Am J Pathol. 1963; 43:1089-104. PMC: 1949785. View

12.

Riley R, Heney D, Jones D, Sutton A, Lambert P, Abrams K . A systematic review of molecular and biological tumor markers in neuroblastoma. Clin Cancer Res. 2004; 10(1 Pt 1):4-12. DOI: 10.1158/1078-0432.ccr-1051-2. View

13.

Wang X, Nagl N, Wilsker D, Van Scoy M, Pacchione S, Yaciuk P . Two related ARID family proteins are alternative subunits of human SWI/SNF complexes. Biochem J. 2004; 383(Pt 2):319-25. PMC: 1134073. DOI: 10.1042/BJ20040524. View

14.

Hansford L, Thomas W, Keating J, Burkhart C, Peaston A, Norris M . Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. Proc Natl Acad Sci U S A. 2004; 101(34):12664-9. PMC: 515113. DOI: 10.1073/pnas.0401083101. View

15.

Tsarovina K, Pattyn A, Stubbusch J, Muller F, Wees J, Schneider C . Essential role of Gata transcription factors in sympathetic neuron development. Development. 2004; 131(19):4775-86. DOI: 10.1242/dev.01370. View

16.

Goldstein A, Brewer K, Doyle A, Nagy N, Roberts D . BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system. Mech Dev. 2005; 122(6):821-33. DOI: 10.1016/j.mod.2005.03.003. View

17.

London W, Castleberry R, Matthay K, Look A, Seeger R, Shimada H . Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group. J Clin Oncol. 2005; 23(27):6459-65. DOI: 10.1200/JCO.2005.05.571. View

18.

Hurley S, Clary D, Copie V, Lefcort F . Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system. J Comp Neurol. 2006; 495(2):202-12. PMC: 2566964. DOI: 10.1002/cne.20887. View

19.

Vernersson E, Khoo N, Henriksson M, Roos G, Palmer R, Hallberg B . Characterization of the expression of the ALK receptor tyrosine kinase in mice. Gene Expr Patterns. 2006; 6(5):448-61. DOI: 10.1016/j.modgep.2005.11.006. View

20.

Yu J, Vodyanik M, Smuga-Otto K, Antosiewicz-Bourget J, Frane J, Tian S . Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007; 318(5858):1917-20. DOI: 10.1126/science.1151526. View