Longitudinal Assessment of D-dimer and Plasminogen Activator Inhibitor Type-1 Plasma Levels in Pregnant Women with Risk Factors for Preeclampsia
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Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.
Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation.
Results: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn't differ between groups.
Conclusion: D-Di was able to discriminate these groups of women at 12-19 and 30-34 weeks of gestation.
Xu Q, Dai L, Chen H, Xia W, Wang Q, Zhu C BMC Pregnancy Childbirth. 2023; 23(1):248.
PMID: 37055718 PMC: 10099697. DOI: 10.1186/s12884-023-05561-1.
Are Endocan Plasma Levels Altered in Preeclampsia?.
Lopes A, Martins S, Dusse L, de Barros Pinheiro M, Alpoim P Rev Bras Ginecol Obstet. 2021; 43(3):232-234.
PMID: 33860506 PMC: 10183914. DOI: 10.1055/s-0041-1728661.
Association of D-dimers with acute kidney injury in pregnant women: a retrospective study.
Wang B, Jiang Q, Wu X J Int Med Res. 2020; 48(11):300060520966899.
PMID: 33251900 PMC: 7708722. DOI: 10.1177/0300060520966899.