Desertomycin G, a New Antibiotic with Activity Against Mycobacterium Tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces Althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva Sp

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2019 Feb 15

PMID 30759848

Citations 20

Authors

Alfredo F Brana

Aida Sarmiento-Vizcaino

Ignacio Perez-Victoria

Jesus Martin

Luis Otero

Juan Jose Palacios-Gutierrez

Jonathan Fernandez

Yamina Mohamedi

Tania Fontanil

Marina Salmon

Santiago Cal

Fernando Reyes

Luis A Garcia

Gloria Blanco

Affiliations

Soon will be listed here.

Abstract

The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete MSM3, isolated from samples of the intertidal seaweed sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as and . Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as and . In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts.

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