Bioactive Sphingolipids in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Overview

Journal Ann Am Thorac Soc

Specialty Pulmonary Medicine

Date 2019 Feb 14

PMID 30759004

Citations 15

Authors

Kengo Koike

Evgeny V Berdyshev

Russell P Bowler

April K Scruggs

Danting Cao

Kelly S Schweitzer

Karina A Serban

Irina Petrache

Affiliations

Soon will be listed here.

Abstract

A better understanding of the pathogenesis of distinct chronic obstructive pulmonary disease (COPD) phenotypes will improve diagnostic and therapeutic options for this common disease. We present evidence that sphingolipids such as ceramides are involved in the emphysema pathogenesis. Whereas distinct ceramide species cause cell death by apoptosis and necroptosis, cell adaptation leads to accumulation of other sphingolipid metabolites that extend cell survival by triggering autophagy. Cigarette smoke-released sphingolipids have been involved in both the initiation and persistence of lung injury via intracellular signaling and paracrine effects mediated via exosomes and plasma membrane-bound microparticles. Strategies to control sphingolipid metabolite production may promote cellular repair and maintenance to treat COPD.

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